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[4] Seino, Y. et al. GIP and GLP-1, the two incretin hormones: Similarities and differences. Journal of Diabetes Investigation. 2010, 1, 8–23. [5] Tilinca, M. et al. A 2021 update on the use of liraglutide in the modern treatment ...
胰高血糖素样肽-1 (GLP-1) 是一种 含30或31个氨基酸的肽激素,源自胰高血糖素原肽(proglucagon)的组织特异性翻译后加工,产生两种截短且等效的生物活性形式,GLP-1 (7–36) 酰胺和GLP-1 (7–37) 。GLP-1是一种肠促胰岛素(incretin):它通过葡萄糖依赖性方式增强胰岛素分泌,以降低血糖水平(所以不要混淆胰高...
[4] Seino, Y. et al. GIP and GLP-1, the two incretin hormones: Similarities and differences. Journal of Diabetes Investigation. 2010, 1, 8–23. [5] Tilinca, M. et al. A 2021 update on the use of liraglutide in the modern treatment of ‘Diabesity’: A narrative review. Medicina (...
et al. A small-molecule oral agonist of the human glucagon-like peptide-1 receptor. Preprint at bioRxiv https://doi.org/10.1101/2020.09.29.319483 (2020). 8. Nauck MA. The rollercoaster history of using physiological and pharmacological properties of incretin hormones to develop diabetes ...
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内分泌因素对GLP-1分泌的影响 01 肠道GLP-1分泌的内分泌调节 L-细胞在肠道的分布(远端肠道丰度高,近端肠道丰度低)表明存在近端至远端协调环路。在该环路中,近端肠产生的神经元和/或内分泌因子影响远端区域的L-细胞GLP-1分泌。 近端肠中L细胞数量虽然较少,也足以在营养摄入后快速诱导GLP-1分泌[52-54]。此时...
CICR:钙诱导的钙释放;LCFA:长链脂肪酸;GLUT2:葡萄糖转运体2;GLP-1:胰高糖素样肽-1;GLP-2:胰高糖素样肽-2;OXM: 胃泌酸调节素;Trpc3:瞬时受体电位通道3;VDCC:电压门控钙通道;SGLT1:钠-葡萄糖共转运体1。 L-细胞对葡萄糖的摄取似乎是通过GLUT2和SGLT1两种途径介导的 (图2) [32,34],其中电压SGLT...
除了TCF7L2之外,已经发现了其他几个与GLP-1诱导的胰岛素分泌减少相关的基因位点,包括GLP-1R位点[73],wolfram综合征1(WFS1)[74]和糜蛋白酶原B1/2(CTRB1/2)[7…
了解GLP-1影响体重的相关机制。 自胰高糖素样肽-1(GLP-1)被发现以来,已然成为一种“多面手”激素——其接二连三的代谢功能被人们发现,远远超出了作为肠促胰素的经典定义。GLP-1众多有益的作用使其受体激动剂逐渐成为更多新兴的治疗领域如脂肪肝、肥胖和神经退行性疾病等的冉冉之“星”药物,而GLP-1的减重作用...