[2] Sarkar, S., Fekete, C., Legradi, G., Lechan, R.M. 2003. Glucagon like peptide-1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Brain...
在大鼠中,GLP-1诱导的利钠和利尿伴随着肾血流量和肾小球滤过率增加[81,82],可能是GLP-1增加了肾入球小动脉的扩张而介导。肾脏去神经会导致GLP-1不能增加肾小球滤过率,降低GLP-1的利钠和利尿作用[81],这也表明GLP-1的利钠利尿作用可能是由于抑制近端小管的钠重吸收,并强调GLP-1需要完整的肾神经支配来增...
在离体灌注大鼠胰腺中,联合输注GLP-1和特异性生长抑素受体2(SSTR2)拮抗剂(PRL-2903)可消除GLP-1对胰高血糖素分泌的抑制作用[39]。虽然这些数据表明生长抑素在介导GLP-1抑制胰高血糖素分泌中发挥了重要作用,但用SSTR2拮抗剂CYN154806处理离体小鼠...
[2] Sarkar, S., Fekete, C., Legradi, G., Lechan, R.M. 2003. Glucagon like peptide-1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Brain Res 985:163-168. [3] Ghosal, S., Packard, A.E.B....
自胰高糖素样肽-1(GLP-1)被发现以来,已然成为一种“多面手”激素——其接二连三的代谢功能被人们发现,远远超出了作为肠促胰素的经典定义。GLP-1众多有益的作用使其受体激动剂逐渐成为更多新兴的治疗领域如脂肪肝、肥胖和神经退行性疾病等的冉冉之“星”药物,而GLP-1的减重作用甚至已经在中国以外的其他一部分国...
[44] Kawai, K., Suzuki, S., Ohashi, S., Mukai, H., Ohmori, H., Murayama, Y., et al. 1989. Comparison of the effects of glucagon-like peptide-1-(1-37) and -(7-37) and glucagon on islet hormone release from isolated perfused canine and rat pancreases. Endocrinology 124:1768-...
Proper water intake helps your gut function efficiently, improving digestion and nutrient absorption, both key factors in GLP-1 secretion. Dehydration can weaken your body’s hormone response, so staying consistently hydrated is essential. Tip: Sip on filtered water throughout the day and consider ...
GLP-1(7-36)和GLP-1(7-37)有相同的促胰岛素分泌作用。研究表明当血糖浓度高于6mmol/L时,GLP-1能显著促进胰岛素分泌;而一旦血糖浓度恢复至正常值则不再继续作用,在临床上这一点对II型糖尿病的治疗十分有用。 GLP-1 is an intestinal hormone secreted by the human body, which is produced by the action...
GLP-1 is a 31-aa peptide hormone and is secreted from intestinal endocrine L cells in two major molecular forms, GLP-1(7–37) and GLP-1(7–36)-amide. Amidation is not always important for its biological activity, and these two molecular forms have similar biological activities. The majori...
(GLP-1) is the most potent insulinotropic hormone known and has been shown to stimulate insulin secretion strongly in patients with type II diabetes, this invention uses GLP-1 or its biologically active analogues in β-cell stimulatory tests in order to test β-cell function in a simple way....