Here, we analyzed direct transcription programs of the AR in VCaP cells using global nuclear run-on sequencing (GRO-seq) and integrated the GRO-seq data with the ARB and VCaP cell-specific TF-binding data. Andr
We used single-cell mRNA sequencing (scRNA-seq) to profile the cell types and states of 16 planarians at different ages and regeneration conditions (Fig.4a). To improve the consistency of tissue sampling from different individuals, we used the posterior ends of the two auricles to mark the ...
CAMBRIDGE, Mass., April 27, 2025 /PRNewswire/ -- Nona Biosciences, a global biotechnology company providing integrated solutions from "Idea to IND" (I to I TM), today announced that its partner, Pfizer, has presented preclinical data on PF-08052666 (HBM9033; SGN-MesoC2), a first-in-cla...
The need for alternatives to chemical control is globally recognized, driven by environmental impacts and increasingly strict regulatory frameworks. Recent studies using next-generation sequencing suggest that insecticides can have complex, indirect effects on animal community structures, underscoring the import...
Speciation is a continuous process driven by genetic, geographic, and ecological barriers to gene flow. It is widely investigated in multicellular eukaryotes, yet we are only beginning to comprehend the relative importance of mechanisms driving the emerg
Gene expression was measured with an Affymetrix MG_U74Av2 oligonucleotide array, while protein expression was examined by performing high-resolution gel-free shotgun MS/MS on a nuclear-enriched cell extract. Both analyses were carried out in triplicate to control for experimental variability. Using ...
Fusion power also has massive potential, but it is even more speculative than next-generation nuclear fission in terms of both technological maturity and time frame. Carbon sequestration could have great impact on reducing c...
MethylFlash Global DNA Hydroxymethylation (5-hmC) ELISA Easy Kit (Colorimetric) FitAmp Blood and Cultured Cell DNA Extraction Kit EpiQuik Total Histone Extraction Kit EpiQuik Nuclear Extraction Kithttps://www.epigentek.com/catalog/images/products/P-1030_kit.jpgReturn window: 7 days ...
This process involves metabarcoding, which can be precisely defined as the use of general or universal polymerase chain reaction (PCR) primers on mixed DNA samples from any origin followed by high-throughput next-generation sequencing (NGS) to determine the species composition of the sample. This ...
Single-cell transcriptomics analysis identified 775 downregulated, 1,525 upregulated and 13,759 unchanged transcripts inAgo2-deficient oocytes (Fig.4cand Supplementary Table5). The upregulated genes may account for theAgo2-null phenotypes because enriched GO terms were related to nuclear division, spi...