onset to death and from visiting to death were 3.0 to 6.0 and 2.0 to 5.0 months,with a mean interval of 4.3 and 3.4 months,respectively.Conclusions The prognosis of diffuse pontine gliomas in children is unfavourable and the survival period of patients is 3 to 6 months without any treatment...
Background While pediatric low-grade glioma/glioneuronal tumors (LGG/LGGNTs) are considered slow-growing, indolent tumors with excellent long-term prognosis, mortality due to the disease is not unknown. Few studies have addressed the cause of death in this population. Methods Retrospective review ...
Gliomas represent the most frequent form of primary brain tumors in adults, the prognosis of which remains extremely poor. Inactivating mutations on the tumor suppressor TP53 were proposed as a key etiological trigger of glioma development. p53 has been recently identified as a transcriptional target ...
pilocytic astrocytoma pilocytic astrocytoma pilocytic astrocytoma excellent prognosis irrespective of treatment modality distinctly different behavior from diffusely infiltrating gliomas 10-year survival 95% vs 17% in ncctg 86-72-51 diffusely infiltrating glioma surgery radiation chemotherapy surgery usually ...
The role of Gliadel wafers in the treatment of high-grade gliomas Glioblastoma multiforme (GBM) is the most aggressive brain tumor. Standard treatment includes surgery, radiation and chemotherapy. Prognosis is dismal with... A Bregy,AH Shah,MV Diaz,... - 《Expert Review of Anticancer Therapy》...
OPG, OS is not as favorable as previously described and ii) patients can be classified into 2 groups depending on risk factors (age, intracranial hypertension, sex and diencephalic syndrome) with an OS rate of 50.4% at 18 years [95% CI: 31.4-66.6] in children with the worst prognosis. ...
oligoastrocytomamolecularfeatures•ploidy–betterprognosiswithdiploidrelativetoaneuploid•proliferation–betterprognosiswithki-67index<3%•co-deletionof1pand19qco-deletionof1p/19q•foundin70-75%oligodendroglioma–35-40%oligoastrocytoma–rarelyinpureastrocytoma•favorableprognosis–139samplesof80patientswithlow...
Diffuse intrinsic pontine glioma (DIPG), or high-grade brainstem glioma (BSG), is one of the major causes of brain tumor-related deaths in children. Its prognosis has remained poor despite numerous efforts to improve survival. Panobinostat, a histone deacetylase inhibitor, is a targeted agent tha...
They comprise 7-8% of all pediatric CNS tumors and are the most frequent of all malignant gliomas in children [1] . Over the past 30 years, the prognosis has remained equally dismal, with [2,3] . A major problem in the treatment of DIPG is its delicate location and diffuse spread in...
Background: The therapeutic efficacy of immune checkpoint inhibitor therapy is highly influenced by tumor mutation burden (TMB). The relationship between TMB and prognosis in lower-grade glioma is still unclear. We aimed to explore the relationships and mechanisms between them in lower-grade glioma....