pediatric oligodendrogliomas most frequently harbor alterations inFGFR1including TKD-duplications or SNVs or BRAF p.V600E (Table1). Recently, the entity polymorphous low-grade neuroepithelial tumor of the young (PLNTY) was described [88]. These tumors invariably possessed oligodendroglioma-like cellula...
pediatric oligodendrogliomas most frequently harbor alterations inFGFR1including TKD-duplications or SNVs or BRAF p.V600E (Table1). Recently, the entity polymorphous low-grade neuroepithelial tumor of the young (PLNTY) was described [88]. These tumors invariably possessed oligodendroglioma-like cellula...
Ectopic HDAC3 expression was correlated with poorer prognosis of children with glioma. In glioma cell lines, inhibition of HDAC3 using siRNA could suppress proliferation and sphere formation, induce G0/G1 arrest and apoptosis, and suppress the migration of glioma cells in comparison with controls. ...
Low-grade glioma is most common in children, whereas in adults, diffuse high-grade gliomas (HGGs) are predominant. In children, diffuse HGGs are rare but have the same dismal prognosis as in adults and, in terms of histopathology, clinical behavior, genetic expression signatures and genetic ab...
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in neurogenesis. One tumor class di... HS ...
Astrocytomas are a group of tumors derived from astrocytic lineages that can present at WHO grade I–IV.Pilocytic astrocytomasare grade I tumors that mostly occur in children and young adults. They show limited invasiveness and have a much better prognosis than other low-grade gliomas, and gener...
Comprehensive analysis of cuproptosis-related genes in prognosis, tumor microenvironment infiltration, and immunotherapy response in gastric cancer Backgrounds Cuproptosis is the most recently identified copper-dependent cell death form that influences tricarboxylic acid (TCA) cycle. However, the relat... ...
Purpose: Immunohistochemical techniques were used to detect the expression of Ki-67, a nuclear proliferation marker, in 180 low-grade glioma tumor specimens to determine whether Ki-67 is a prognostic predictor of survival or tumor recurrence. Methods and Materials: A clinical database of 180 low-...
Glioma is the most common primary malignant brain tumor. Despite significant advances in the past decade in understanding the molecular pathogenesis of thi
Phase I Study of Cilengitide (EMD 121974) in Children With Refractory Primary Brain Tumors. Pediatric Brain Tumor Consortium, 2003. Phase I Study of EMD 121974 in Patients With Advanced Solid Tumors. University of Colorado Cancer Center at University of Colorado Health Sciences Center, 2003 Frisch...