and the prognosis of most patients is poor. At present, the first-line treatment methods mainly include surgery,radiotherapy, and chemotherapy, have clear guidance and recommendations for initially diagnosed glioma, and clinical treatment is relatively standardized, which can inhibit tumormetastasisand ...
Intratumor spatial heterogeneity facilitates therapeutic resistance in glioblastoma (GBM). Nonetheless, understanding of GBM heterogeneity is largely limited to the surgically resectable tumor core lesion while the seeds for recurrence reside in the unre
The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors. Despite advancements in therapeutic regimens, the prognosis remains poor for patients with malignant gliomas. Specificity has been an elusive goal for curr... PE Fecci,DA ...
Herein, we reinforce a role for IL-33 as a major regulator of the brain tumor environment and provide mechanistic insight into how this environment promotes tumorigenesis. We find that ~50% of surgical samples that cover the molecular and clinical heterogeneity of GBM patients, and their correspon...
Malignant gliomas are highly lethal brain tumors that portend a dismal prognosis for patients. Despite modern surgical and medical treatments, the median survival for glioblastoma patients (WHO grade IV astrocytoma) remains only 14.6 months (Stupp et al., 2005), emphasizing a need for improved ther...
factors and tumor total resection (RR=0.55, 95% CI: 0.37-0.84) and preoperative KPS score ≥70 points (RR=0.70, 95% CI: 0.51-0.95) protective prognostic factors (P45 years), higher tumor grade, non-total resection and low preoperative KPS scores are more likely to undergo bad prognosis....
Glioblastoma (GBM) is the most common primary brain tumor occurring in America. Despite recent advances in therapeutics, the prognosis for patients with newly diagnosed GBM remains dismal. As these tumors characteristically show evidence of angiogenesis (neovascularization) there has been great interest ...
According to the fifth edition of the WHO Classification of Tumors of the Central Nervous System (WHO CNS5), standard of care and prognosis of gliomas can be dramatically different. Generally, circumscribed gliomas are usually benign and recommended to early complete resection, with chemotherapy if ...
This in-frame deletion mutation splits a codon resulting in the creation of a novel glycine at the fusion junction between normally distant parts of the molecule and producing a sequence re-arrangement which creates a tumor-specific epitope for cellular or humoral immunotherapy in patients with MGs...
The most common of primary brain tumor is generally associated with very high rates of mortality (ca. 90%) and low survival (about 1 year). Moreover, glioma have a poor prognosis and limited treatment options. The reference drug is temozolomide (TMZ) which only increases the patients' life...