摘要: Gliomas represent the most frequent form of primary brain tumors in adults, the prognosis of which remains extremely poor. Inactivating mutations on the tumor suppressor TP53 were ... 查看全部>> 展开 关键词: Glioblastoma cells Human brain glioma p53 Parkin Transcription Tumor grade 收藏...
Glioma gradeTumor subregionMultiparametric magnetic resonance imagingRadiomicsPredicting glioma grade plays a pivotal role in treatment and prognosis. However, several current methods for grading depend on the characteristics of the whole tumor. Predicting grade by analyzing tumor subregions has not been ...
failure of complete resection of the enhancing lesions leads to substantially worse prognosis reducing the mean overall survival from 15.2–28.6 months with complete resection to 4.9–16.9 months with non-complete resection (Fig.3a). Therefore, even a small residual tumor core may induce much worse...
grade gliomas slow growing but eventually fatal 80% transform to high-grade histological subtypes astrocytoma – 50% fibrillary protoplasmic gemistocytic behaves more like anaplastic astrocytoma oligodendroglioma – 28% oligoastrocytoma – 22% prognosis 42,688 patients diagnosed between 1995-2006 astrocytoma...
These results provide the first evidence that MTA3 expression was decreased in human glioma and negatively associated with prognosis of patients, suggesting that MTA3 may play a tumor suppressor role in glioma. 展开 关键词: MTA3 Glioma Immunohistochemistry Prognosis DOI: 10.1007/s10072-015-2252-...
(ie, who grade i, ii, iii, and iv). 2 we generally define who grade i–ii tumor as low-grade glioma (lgg), and grade iii–iv as high-grade glioma (hgg). numerous studies have proved that glioma is associated with high recurrence rate and poor prognosis....
Lower BCYRN1 expression was related to poor prognosis of glioma patients. Furthermore, we found that BCYRN1 affected the proliferation, apoptosis, migration, invasion abilities in vitro and inhibited the tumor formation in vivo. In addition, our study revealed a mechanism that BCYRN1 competitively...
An NF-kappa B signature predicts low-grade glioma prognosis: a precision medicine approach based on patient-derived stem cells An NF-kappa B signature predicts low-grade glioma prognosis: a precision medicine approach based on patient-derived stem cells Cesselli,Daniela,Mangoni,... 被引量: 0...
The prognosis is grim with a median survival of only 15 months underlining the importance to develop new therapeutic strategies. The recent development of the "tumor stem cell" (TSC) concept in hemopathies has been secondarily applied to gliomas with the identification of subpopulations of GBM ...
Prediction of glioma is crucial to provide a precise treatment plan to optimize the prognosis of children with glioma. However, studies on the grading of pediatric gliomas using radiomics are limited. Meanwhile, existing methods are mainly based on only radiomics features, ignoring intuitive information...