Our model achieves a mean dice score of 89.78%, 82.53% and 76.54% for the whole tumor, tumor core and enhancing tumor respectively in segmentation task and 67.90% in overall survival prediction task with the validation set of BraTS 2018 challenge. It obtains a mean dice accuracy of 87.315%,...
It is now clear that the presence of diverse cell types within tumors with different activated states can dramatically impact therapeutic response10and together with the complex interaction with the extracellular matrix, tumor vasculature, and the normal stromal compartment, including immune cells and fue...
thesurvival timeof patients. However,glioma cellsshow invasive growth, and the tumor is easy to spread and metastasize, causing damage to the surrounding normal tissue cells. Surgical treatment is difficult to eradicate, with a high recurrence rate. In addition, radiotherapy and chemotherapy have ...
Malignant gliomas are highly lethal brain tumors that portend a dismal prognosis for patients. Despite modern surgical and medical treatments, the median survival for glioblastoma patients (WHO grade IV astrocytoma) remains only 14.6 months (Stupp et al., 2005), emphasizing a need for improved ther...
Survival predictionSegmentation of brain tumor from magnetic resonance imaging (MRI) is a vital process to improve diagnosis, treatment planning and to study the difference between subjects with tumor and healthy subjects. In this paper, we exploit a convolutional neural network (CNN) with hyper...
Localization of gelatinase-A and gelatinase-B mRNA and protein in human gliomas Malignant gliomas maintain a poor prognosis and survival rate due to their marked local invasive growth and neovascularization. Matrix metalloproteinases (... SA Raithatha,M Huong,RN Barry,... - 《Neurooncology》 被引...
down-regulation of Nanog-targeted genes, which are associated with glioblastoma patient survival. Moreover, treatment of human glioma stem cells (hGSCs) with Lck-I, results in significant inhibition of self-renewal and tumor-sphere formation. The involvement of Lck in different levels of glioma ...
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults [1] and carries a grim prognosis. Infiltrative nature of diffuse gliomas makes it difficult to eliminate microscopic disease despite macroscopic gross total resection. Recurrence of GBM is inevitable, and the median overall...
OBJECTIVE: Glioblastoma multiforme (GBM) has a poor prognosis. The purpose of this systematic review and meta-analysis was to analyze the outcomes of clinical trials which compared immunotherapy with conventional therapy for the treatment of malignant gliomas. METHODS: PubMed, Cochrane and Google Schol...
Glioblastoma is a highly aggressive and malignant type of brain cancer that originates from glial cells in the brain, with a median survival time of 15 months and a 5-year survival rate of less than 5%. Regulated cell death (RCD) is the autonomous a