While the plasticity of epithelial stem cells is well characterized, the identity and role of the niche has not been delineated in metaplasia. Here, we show that Gli1 mesenchymal stromal cells (MSCs), previously shown to contribute to myofibroblasts during scarring, promote metaplastic ...
Gli1+mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung Monica Cassandras, Chaoqun Wang, Jaymin Kathiriya, Tatsuya Tsukui, Peri Matatia, Michael Matthay, Paul Wolters, Ari Molofsky, ...
Mesenchymal stem cellsGli1AngiogenesisHif-1αBoneBackground: Mesenchymal stem/stromal cells (MSCs) reside in the perivascular niche and modulate tissue/organ homeostasis, whereas little is known about whetherdoi:10.2139/ssrn.3495592Chen, JiLi, Meng...
Col2+, Acan+, or Osx+cells have all been shown to produce osteoblasts and BMSCs in both growing and adult (4 months of age) mice10,11. However, it is not clear how those perinatal progenitors relate to the Lepr+stromal cells that generate...
gastrointestinal stromal tumours Mesenchymal tumours derived from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis of the gut. They are caused by mutation inkitor in platelet derived growth factor receptor A (PDGFRA) genes. ...
Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells J Biol Chem, 278 (2003), pp. 18506-18513 View PDFView articleView in ScopusGoogle Scholar 26 J. Jiang, C.C. Hui Hedgehog signaling in development and cancer Dev Cell, 15 (200...
[8]Onoue T,Uchiida D,Begum NM,et al.Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells.Int J Oncol,2006,29(5):1133. [9]Yang J,Mani SA,Donaher JL,et al.Twist,a master regulator of morphogenesis,plays an esse...
目的:种植体周充足的骨量及角化龈是维持其长期稳定的关键要素,各种口腔软硬组织增量技术已成为获取种植成功的预防性或治疗性策略.而充足的血供是保证软硬组织再生成功的先决条件.Sonic hedgehog(SHH)信号通路不仅能影响骨形成和改建,还能调控血管发育和再生,并能诱导间充质干细胞(mesenchymal stem cells, MSCs)分化为不...
While the plasticity of epithelial stem cells is well characterized, the identity and role of the niche has not been delineated in metaplasia. Here, we show that Gli1 mesenchymal stromal cells (MSCs), previously shown to contribute to... M Cassandras,C Wang,J Kathiriya,... - 《Nature Cel...
Oncology 70: 378 – 389 Mukherjee S, Frolova N, Sadlonova A, Novak Z, Steg A, Page GP, Welch DR, Lobo-Ruppert SM, Ruppert JM, Johnson MR, Frost AR (2006) Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer. Cancer ...