Hedgehog(Hh)信号通路在哺乳动物的组织发育和器官形成中发挥重要作用.Gli1是Hh信号通路中重要的转录因子之一,并已被证实为间充质干细胞(MSCs)可靠的体内标记物.Gli1阳性MSCs具有自我更新能力和多向分化潜能,在牙及牙周组织中可分化为多种功能细胞,包括成牙本质细胞,成牙骨质细胞,成纤维细胞和成骨细胞,参与组织的...
外泌体是直径为30-100nm的细胞外囊泡，可以携带RNA，并通过在细胞之间传递信息和调节细胞间通讯来影响细胞功能。来源于MSCs的外泌体通过分泌细胞因子和诱导细胞分化来促进损伤后的血管修复，并广泛用于心血管疾病。同时，外泌体是再生医学中非常有前途的纳米囊泡，携带药物或核酸调节组织损伤修复和再生，在体内显示出...
外泌体是直径为30-100nm的细胞外囊泡,可以携带RNA,并通过在细胞之间传递信息和调节细胞间通讯来影响细胞功能。来源于MSCs的外泌体通过分泌细胞因子和诱导细胞分化来促进损伤后的血管修复,并广泛用于心血管疾病。同时,外泌体是再生医学中非常有前途的纳米囊泡,携带药物或核酸调节组织损伤修复和再生,在体内显示出安全性...
(MSCs), previously shown to contribute to myofibroblasts during scarring, promote metaplastic differentiation of airway progenitors into KRT5+basal cells. During fibrotic repair,Gli1+MSCs integrate hedgehog activation signalling to upregulate BMP antagonism in the progenitor niche that promotes metaplasia. ...
BoneBackground: Mesenchymal stem/stromal cells (MSCs) reside in the perivascular niche and modulate tissue/organ homeostasis, whereas little is known about whetherdoi:10.2139/ssrn.3495592Chen, JiLi, MengLiu, An-QiZheng, Chen-XiBao, Li-HuiChen, Kai...
5. Work in the past two decades with cell sorting techniques has revealed that cell surface markers for MSCs are likely complex and variable especially following expansion in vitro6,7. Nonetheless, Pdgfra and Sca-1 have been useful for prospective enrichment of MSCs in the mouse8. Recently, ...
目的:种植体周充足的骨量及角化龈是维持其长期稳定的关键要素,各种口腔软硬组织增量技术已成为获取种植成功的预防性或治疗性策略.而充足的血供是保证软硬组织再生成功的先决条件.Sonic hedgehog(SHH)信号通路不仅能影响骨形成和改建,还能调控血管发育和再生,并能诱导间充质干细胞(mesenchymal stem cells, MSCs)分化为不...
Here, we show that Gli1 mesenchymal stromal cells (MSCs), previously shown to contribute to... M Cassandras,C Wang,J Kathiriya,... - 《Nature Cell Biology》 被引量: 0发表: 2020年 Identification of Gli1‐interacting proteins during simvastatin‐stimulated osteogenic differentiation of bone ...
43 Another recent study has indirectly co-cultured cancer cells and bone marrow mesenchymal stem cells (BM-MSCs) without direct cell contact: a paracrine effect of cancer cells has been observed by secreting soluble factors, such as TGF-β, which promoted a more stem-like state of non-CSCs....
来源于MSCs的外泌体通过分泌细胞因子和诱导细胞分化来促进损伤后的血管修复,并广泛用于心血管疾病。同时,外泌体是再生医学中非常有前途的纳米囊泡,携带药物或核酸调节组织损伤修复和再生,在体内显示出安全性和有效性。LncRNA-ANCR在先前的研究中已经显示出抑制成骨细胞分化的能力。在人成骨细胞分化过程中,lncRNA ...