Both reactions are catalyzed by one enzyme, the bifunctional UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). ManNAc 6-P is then condensed with phosphoenolpyruvate forming sialic acid 9-P. This compound is further metabolized to CMP-sialic acid, which is transported to the Golgi apparatus, and ...
UDP- N -acetylglucosamine 2-epimerase/ N -acetylmannosamine kinase is the key enzyme of sialic acid biosynthesis in vertebrates. It catalyzes the first two steps of the cytosolic formation of CMP- N -acetylneuraminic acid from UDP- N -acetylglucosamine. In this review we give an overview of...
In conclusion, in human malignant lymphoma, ceramide and its metabolite-induced cell death is regulated by the amount of sialic acid on the cell surface which in turn is regulated by mRNA expression of UDP-GlcNAc2-epimerase. 展开 关键词: 1-Phosphatidylinositol 3-Kinase Annexin A5 Caspases Cell ...
role of glcnac 2-epimerase 1 glcnac 2-epimerase can serve a catabolic role in sialic acid metabolism 来自 dx.doi.org 喜欢 0 阅读量: 20 作者:SJ Luchansky,KJ Yarema,S Takahashi,CR Bertozzi 摘要: Sialic acid is a major determinant of carbohydrate-receptor interactions in many systems pertinent...
GNE, NT (GNE, GLCNE, Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase, UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acet ...
UDP-GlcNAc 4-epimerase from Plesiomonas shigelloides O17, Recombinant| 基本信息 更多信息 中文名称: 中文同义词: 英文名称: UDP-GlcNAc 4-epimerase from Plesiomonas shigelloides O17, Recombinant 英文同义词: UDP-GlcNAc 4-epimerase from Plesiomonas shigelloides O17, Recombinant CAS号: 9024-16-2 分子...
正利用DNase I進行DNA shuffling的工作,在未來的實驗中準備以GFPuv的基因作為一個篩選的marker,當作大量篩選的一個工具.以期在進行DNA洗牌重組之後能幫助大量篩選出能表達蛋白質且具有比原產物活性較高的重組基因,進而篩選出對ATP反應子需求量降低的GlcNAc 2-epimerase,而大幅降低反應成本,達到幫助工業化生產之目的. c ...
This substrate is converted to N -acetylmannosamine (ManNAc) by a specific UDP-GlcNAc 2-epimerase and then phosphorylated to ManNAc 6-P (Fig.134.1). Both reactions are catalyzed by one enzyme, the bifunctional UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). ManNAc 6-P is then condensed ...
The bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) plays a key role in sialic acid production. It is different from the non-hydrolyzing enzymes for bacterial cell wall biosynthesis and it is feed-back inhibited by the downstream product CMP-Neu5Ac. Here the complex crystal ...
This substrate is converted to N-acetylmannosamine (ManNAc) by a specific UDP-GlcNAc 2-epimerase and then phosphorylated to ManNAc 6-P (Fig. 134.1). Both reactions are catalyzed by one enzyme, the bifunctional UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). ManNAc 6-P is then condensed ...