This substrate is converted to N-acetylmannosamine (ManNAc) by a specific UDP-GlcNAc 2-epimerase and then phosphorylated to ManNAc 6-P (Fig. 134.1). Both reactions are catalyzed by one enzyme, the bifunctional UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). ManNAc 6-P is then condensed ...
UDP- N -acetylglucosamine 2-epimerase/ N -acetylmannosamine kinase is the key enzyme of sialic acid biosynthesis in vertebrates. It catalyzes the first two steps of the cytosolic formation of CMP- N -acetylneuraminic acid from UDP- N -acetylglucosamine. In this review we give an overview of...
In conclusion, in human malignant lymphoma, ceramide and its metabolite-induced cell death is regulated by the amount of sialic acid on the cell surface which in turn is regulated by mRNA expression of UDP-GlcNAc2-epimerase. 展开 关键词: 1-Phosphatidylinositol 3-Kinase Annexin A5 Caspases Cell ...
GNE, NT (GNE, GLCNE, Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase, UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acet ...
UDP-GlcNAc 4-epimerase from Plesiomonas shigelloides O17, Recombinant| 基本信息 更多信息 中文名称: 中文同义词: 英文名称: UDP-GlcNAc 4-epimerase from Plesiomonas shigelloides O17, Recombinant 英文同义词: UDP-GlcNAc 4-epimerase from Plesiomonas shigelloides O17, Recombinant CAS号: 9024-16-2 分子...
This substrate is converted to N -acetylmannosamine (ManNAc) by a specific UDP-GlcNAc 2-epimerase and then phosphorylated to ManNAc 6-P (Fig.134.1). Both reactions are catalyzed by one enzyme, the bifunctional UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). ManNAc 6-P is then condensed ...
This substrate is converted to N-acetylmannosamine (ManNAc) by a specific UDP-GlcNAc 2-epimerase and then phosphorylated to ManNAc 6-P (Fig. 134.1). Both reactions are catalyzed by one enzyme, the bifunctional UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). ManNAc 6-P is then condensed ...
摘要: UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase is the key enzyme of sialic acid biosynthesis in vertebrates. It catalyzes the first two steps of the cytosolic formation of CMP-N-acetyl关键词: Bifunctional enzyme GNE myopathy GNE-opathy N-Acetylneuraminic acid biosynthesis ...
The bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) plays a key role in sialic acid production. It is different from the non-hydrolyzing enzymes for bacterial cell wall biosynthesis and it is feed-back inhibited by the downstream product CMP-Neu5Ac. Here the complex crystal ...
UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal tran... Keppler,T O. - 《Science》 被引量: 517发表: 1999年 A Bifunctional Enzyme...