This substrate is converted to N-acetylmannosamine (ManNAc) by a specific UDP-GlcNAc 2-epimerase and then phosphorylated to ManNAc 6-P (Fig. 134.1). Both reactions are catalyzed by one enzyme, the bifunctional UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). ManNAc 6-P is then condensed ...
UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): a master regulator of sialic acid synthesis. Top Curr Chem. (2015) 366:97-137. doi: 10.1007/128_2013_... H Moller,V Bohrsch,S Hinderlich - Meeting of the Society-for-glycobiology 被引量: 2发表: 2009年 [Topics in Current Chemistry] Sialo...
On the other hand, the hyposialylated 3D2 clone was more sensitive to C6-ceramide-induced cell death. Neuraminidase treatment or knockdown by siRNA of uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc2-epimerase), which is a key enzyme of sialic acid biosynthesis, enhanced the ...
UDP-N-acetylglucosamine 2-epimeraseN-acetylmannosamine kinase… 文档格式: .pdf 文档大小: 950.2K 文档页数: 7页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 论文--期刊/会议论文 文档标签: UDP-N-acetylglucosamine2-epimeraseN-acetylmannosaminekinase ...
Overproduction of NeuAc is believed to result from loss of feedback inhibition of uridinediphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) by cytidine monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac). We report the cloning and characterization of human UDP-GlcNAc 2-epimerase ...
GNE, NT (GNE, GLCNE, Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase, UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acet ...
PHD1 编码一个UDP-葡萄糖差向异构酶(UDP-glucose epimerase, UGE),该酶在植物中是保守的,定位在叶绿体。一个水稻碳同化和产量降低的矮小突变体(photoassimilate defective1, phd1),其UGE 活性是野生型的50%,此外底物UDP-葡萄糖和UDP-半乳糖的分别在叶绿体中**升高和降低,表明PHD1 调控着质体中大部分的UGE...
UDP-glucose 4-epimerase (GalE)催化糖代谢中UDP-glucose (UDP-Glc)和udp -半乳糖(UDP-Gal)的相互转化,或udp – n -乙酰氨基葡萄糖(UDP-GlcNAc)和udp – n -乙酰氨基半乳糖(UDP-GalNAc)的相互转化。 GalEs属于短链脱氢酶/还原酶超家族,使用保守的“瞬态酮中间体”机制,具有可变的底物特异性。
科研供应UDP-GlcNAc 4-epimerase (WbgU) 差向异构酶 西安齐岳生物科技有限公司是国内*的糖科学工具酶供应商;现货供应一系列的酶产品和糖化学产品;糖科学工具酶(糖基转移酶、糖核苷酸合成酶、PNGaseF)、糖核苷酸、糖标准品(单糖衍生物、寡糖、N-糖链、SGP糖肽、人乳寡糖)同时,公司还推出客户定*务,提供糖肽合成、复...
Only a Gne cDNA encoding UDP-GlcNAc 2-epimerase:ManNAc kinase rescued PSA synthesis. In an in vitro UDP-GlcNAc 2-epimerase assay, Lec3 cells had no detectable UDP-GlcNAc 2-epimerase activity, and Lec3 cells grown in serum-free medium were essentially devoid of sialic acid on glycoproteins....