Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology A. L. Madsen S. Bonàs-Guarch T. Hansen Nature Metabolism(2024) Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex tr...
We next investigated whether the observed epigenetic and genetic aberrations in ACC are associated with a change of the respective protein expression. Immunohistochemical stainings were performed on a tissue microarray including 23 ACC from cohort 1 and 39 ACC from cohort 2 as well as 8 normal panc...
Yellow-feathered chickens (YFCs) have a long history in China. They are well-known for the nutritional and commercial importance attributable to their yellow color phenotype. Currently, there is a huge paucity in knowledge of the genetic determinants res
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The objectives of this study were to (i) explore the patterns of population structure in the pollen parent heterotic pool using different methods, (ii) investigate the genome-wide distribution of genetic diversity, and (iii) assess the extent and genome-wide distribution of linkage disequilibrium ...
Here, we make use of genome-wide CRISPR-Cas9 knockout screens in murine SMB21 and human DAOY cells, in order to unravel genetic dependencies and drug-related genetic interactors that could serve as alternative therapeutic targets for SHH-MB. Our screens reinforce SMB21 cells as a faithful ...
This genetic association study investigates the genetics of depression across multiple data sets of individuals of East Asian and European descent living
To examine genetic relationships among those six goose breeds, the PCA (Fig. 1A–C), NJ phylogeny and admixture (K = 4) analyses were performed using the whole-genome sequencing data (Fig. 1E). PC1, PC2, and PC3 in the PCA explained that the proportions of total variance were 21....
This genome-wide pleiotropic association study sequentially investigates the pleiotropic associations from genetic and biological pathways to disentangle
This has led to new approaches for simultaneous discovery and genotyping of dense genetic markers on a scale that represents a step change from the state of the art prior to this technology [12]. One such approach is Restriction-site Associated DNA (RAD) sequencing (RAD-Seq), which is a ...