浅谈全基因组关联研究 (Genome-wide association study,GWAS) 迄今为止,全基因组关联研究(以下简称GWAS)发展已有二十多年了。这二十多年间,随着样本数的越来越大以及基因芯片的物美价廉,GWAS也得到了更多的发展,科学家们发现了大量和人类疾病以及其它表型相关联的基因,在此基础上,GWAS还推动了孟德尔随机化和多基因风...
Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal ampl...
Hardly any genome-wide investigations of the population structure and genetic basis of the unique YFC phenotypic traits have been conducted, a major drawback in rational improvement and conservation of these chickens. In this study, we sought to accomplish an extensive sequencing of YFC populations ...
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P < 5 × 10
Genome-wide variability and selection signatures in Italian island cattle breeds. Anim Genet. 2018;49(5):371–83. Article CAS PubMed Google Scholar Li D, Li Y, Li M, Che T, Tian S, Chen B, Zhou X, Zhang G, Gaur U, Luo M. Population genomics identifies patterns of genetic ...
本期我们对GWAS分析做一些简单介绍。GWAS,全称genome-wide association study,即全基因组关联分析。GWAS是一种用于识别遗传区域(基因座)和性状(包括疾病)之间关联的无假设方法, 在群体水平上解析性状遗传基础的方法。这是非常书面的表述,非常绕口和难以理解。
Genome-widegenetic correlationbetween BW and a range of traits and diseases in later life. 7、基因集富集分析(Gene set enrichment analysis) 8、与表型相关位点的层次聚类分析(Hierarchical clustering) 9、蛋白质相互作用网络分析(Protein–protein interaction network analyses) ...
1 Genetic stocks and experimental design To investigate low-temperature tolerance in cereals we compared the response to cold of four near-isogenic lines (NILs) previously generated [16] from two cultivars, one a non-hardy spring wheat (spring Manitou) and the other a very cold-hardy winter wh...
Genome Medicineis calling for submissions to a new Collection on the interpretation and application of genetic and genomic variation in the prevention, diagnosis, and treatment of neurological disorders, guest edited by Daniel Geschwind and Jessica Rexach. Deadline 2 September 2025. ...
Genome-wide analysis of gene expression is the study of transcription at a genomic scale, also known as transcriptomics. Typically relying on data from microarrays or high throughput sequencing, it can determine what genes or transcript isoforms are enriched in a particular cell or tissue type, con...