We have installed the gem-dimethyl moiety on the norbornane ring system containing a cage framework by a late-stage synthetic manipulation involving the hydrogenolysis of the cyclopropane ring with the aid of Adams' catalyst (PtO2). Several cage molecules containing methyl substituents were ...
We have installed the gem-dimethyl moiety on the norbornane ring system containing a cage framework by a late-stage synthetic manipulation involving the hydrogenolysis of the cyclopropane ring with the aid of Adams' catalyst (PtO2). Several cage molecules containing methyl substituents were ...
Conformation determining torsion angles are compared to those from molecular mechanics calculations and to the corresponding data for an analogous dipyrrylmethane (2) with no gem-dimethyl moiety. The crystal structures of 1 and 2 differ significantly: 1 adopts the +ac,+ac or −ac,−ac ...
With the sulfur half being nonessential to its high reactivity and selectivity towards H_2S, we highlight the unique flexibility of our design by improving its biocompatibility and tissue specificity through structural modifications of its sulfide moiety.S. Israel SuarezRynne AmbroseMadison A. Kalk...
The synthesis and photolysis of the spirocyclobutanones 4鈥 7 incorporating a cyclohexa-, cyclohepta- and cyclooctadiene moiety, respectively, is described. On triplet excitation, these compounds undergo isomerization via a 1,2-acyl shift involving one or both double bonds of the diene system. The...
With the sulfur half being nonessential to its high reactivity and selectivity towards H2S, we highlight the unique flexibility of our design by improving its biocompatibility and tissue specificity through structural modifications of its sulfide moiety. To broaden our understanding of hydrogen sulfide ...
-cypermethric acid, a cheap source of the cyclopropane ring required in the targeted compound, and utilizes the cis -orientation of the 2,2-dichlorovinyl and carboxylic acid side arms, already present in the starting material, to effect a diastereoselective construction of the proline moiety.doi...
In order to characterize the mechanism of gem‐dimethyl group formation, with a goal toward engineering of novel compounds containing this moiety, the gem‐dimethyl group producing polyketide synthase (PKS) modules of yersiniabactin and epothilone were characterized using mass spectrometry. The work ...