NMR studies of monomer and trimer models showed that the NCα‐gem‐dimethylated groups exert complete cis control on the backbone amide conformation. Lastly, a preliminary molecular modeling study gave an insight into the preferred orientation of the substituents of the NCα‐gem‐dimethyl side ...
Synthesis of trifluoromethylated and gem- difluoromethylenated biologically interesting compounds from fluorine- containing synthons. Synlett. 1052-1072 (2011).Qing F-L, Zheng F (2011) Synthesis of trifluoromethylated and gem-difluoromethylenated biologically interesting compounds from fluorine-...
Purification and biophysical properties of oleanes gem-dimethylated isolated from Gymnema sylvestre. No. Chromatographic conditions Melting point (°C) IR analysis (cm−1) Mass analysis [α]D (Concentration, Solvent) HPLC (RP-C18; CH3OH/H20, 30:1) HPLC (RP-C18; CH3OH/H20, 4:1) 17 ...
Pd‐Catalyzed Selective Carbonylation of gem‐Difluoroalkenes: A Practical Synthesis of Difluoromethylated Estersdoi:10.1002/anie.201813801Liu, JiawangYang, JiFerretti, FrancescoJackstell, RalfBeller, MatthiasAngewandte Chemie International Edition
Synthesis of trifluoromethylated and gem- difluoromethylenated biologically interesting compounds from fluorine- containing synthons. Synlett. 1052-1072 (2011).Qing F-L, Zheng F (2011) Synthesis of trifluoromethylated and gem-difluoromethylenated biologically interesting compounds from fluorine-...
(2013) C-4 Gem-dimethylated oleanes of Gymnema sylvestre and their pharmacological activities. Molecules, 18, 14892-14919.Di Fabio, G.; Romanucci, V.; Zarrelli, M.; Giordano, M.; Zarrelli, A. C-4 gem-dimethylated oleanes of Gymnema sylvestre and their pharmacological activities. ...
A robust Stille gem -difluoroallylation of arylstannanes with 3-bromo-3,3-difluoropropenes has been established. The catalyst was found to exert critical effect on the reaction chemoselectivity. By using Pd(OH) 2 /C as the catalyst, a series of 3-(hetero)aryl/vinyl-3,3-difluoropro...
difluoromethylated estersfluoroalkenespalladiumselectivityThe first catalyst for the alkoxycarbonylation of gem-difluoroalkenes is described. This novel catalytic transformation proceeds in the presence of Pd(acac)(2)/1,2-bis((di-tert-butylphosphan-yl)methyl)benzene (btbpx) (L4) and allows for an...
Guo, X. Zhang, Highly selective gem- difluoroallylation of organoborons with bromodifluoromethylated alkenes catalyzed by palladium, J. Am. Chem. Soc. 136 (2014) 1230-1233.Min Q-Q, Yin Z, Feng Z, Guo W-H, Zhang X. Highly selective gem-difluoroallylation of organoborons with bromodi...
The synthesis of bo rylated orga nofluorines is of great interest due to their potential values as synthons in modular construction of fluorine-containing molecules.Reported herein is a rhodium-catalyzed hydrobo ration of arylgem-difluoroalkenes leading to a series of α-difluoromethylated benzyl...