The high enantioselectivity is enabled by an appropriate oxime directing group, sterically biased gem-groups in the C-H substrate, and high reactivity of the amidating reagent.doi:10.1002/ange.202014080Liu, BingxianXie, PengfeiZhao, JieWang, JuanjuanWang, ManmanJiang, YuqinChang, JunbiaoLi, Xingwei...
The influence of a gem-dimethyl group on an iodine-induced cyclisation of ω-alkenoic acids, leading to seven-membered and medium ring lactones was studied.doi:10.1016/0040-4039(93)88076-UBruno SimonotGérard RousseauTetrahedron Letters
The gem‐dimethyl groups in polyketide‐derived natural products add steric bulk and, accordingly, lend increased stability to medicinal compounds, however, our ability to rationally incorporate this functional group in modified natural products is limited. In order to characterize the mechanism of gem...
Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity. Bioorganic Med. Chem. Lett. 2012; 22 :4084–4088. doi: 10.1016/j.bmcl.2012.04.073. [ Cross Ref ]Keck, G.E.; Poudel, Y.B.; Rudra, A.; Stephens, J.C.; Kedei, N.; Lewin, N.E.;...
The introduction of a gem-dimethyl group on the backbone of the ligand leads to a significant variation in the properties of the corresponding complexes, which originate from a different conformational behaviour.Forgács, A.Giovenzana, G.B.Botta, M.Brücher, E.Tóth, I.Baranyai, Z....
A crystal structure determination of the new dipyrrylmethane diethyl-2,3,5,5,7,8-hexamethyl-5,10-dihydrodipyrrin-1,9-dicarboxylate (1) is only the third reported for a dipyrrylmethane and the first with a gem-dimethyl group at the bridging carbon atom. Conformation determining torsion ...
CYCLOBUTANECYCLOBUTANONESCARBONYL compoundsCyclobutanes with a gem‐dimethyl group are common motifs in natural products. However, strategies for constructing enantioenriched gem‐dimethyl cyclobutanes are still underdeveloped. Herein, we report an enantioselective approach to synthesize a broad...
Suppression of mutagenic activity of a series of 5HT2c receptor agonists by the incorporation of a gem-dimethyl group: SAR using the Ames test and a DNA unwinding assay. Mutagenesis. 1998;13(4):397-403.Albertini S, Bos M, Gocke E, Kirchner S, Muster W, Wichmann J. Suppression of ...
FIELD: chemistry.;SUBSTANCE: invention concerns a method of obtaining new condensed amino-1,3,5-triazines with gem-dimethyl group of the formula with acetone in the presence of a catalyst, followed by extraction of the target products.;EFFECT: antifolate effect of the obtained compounds allowing...
A study was made of the hydrogenolysis of gem-dimethylcyclobutane in the presence of Pt, Pd, Rh, Ir, and Ru, deposited on active charcoal. On all of the studied catalysts the hydrogenolysis of gem-dimethylcyclobutane proceeds selectively at the unshielded bond, with the formation of 2,2-...