2008 . Caenorhabditis elegans gelsolin-like protein 1 is a novel actin filament-severing protein with four gelsolin-like repeats . J Biol Chem 283 : 26071 – 26080 .Klaavuniemi T, Yamashiro S, Ono S. Caenorhabditis elegans gelsolin-like protein 1 is a novel actin filament-severing protein ...
binding site of G1. Finally, to tighten up the gelsolin–actin complex, Ca2+binds to the two type-1 sites shared between actin and gelsolin, which might explain the very high affinity of gelsolin to actin as recently demonstrated for plant villin, a gelsolin-like protein (Mierset al., ...
Gelsolin is a 80 kDa protein displaying six homologous, gelsolin-like, domains (named G1 to G6) existing as two alternative splicing variants: a 24-residue shorter intracellular form and a variant secreted in the bloodstream1,2. Both isoforms bind actin fibrils, severing the filaments and ...
Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro. Oncogene. 2004;23(42):6997–7004. https://doi.org/10.1038/sj.onc.1207925. Alessi DR et al. Dec., Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 1996;15...
1987: Organization of stress fibers in cultured fibroblasts after extraction of actin with bovine brain gelsolin-like protein Experimental Cell Research 173(1): 244-255 Doi, Y.K.; Banba, M.; Vertut-Doï, A. 1991: Cysteine-374 of actin resides at the gelsolin contact site in the EGTA-...
uncontrolled attachment strategy, the number of protein domains being unfolded varies in different unfolding traces, as has been well-documented25. The force-extension curves of (GB1–G6)4are characterized by saw-tooth-like unfolding patterns (Fig. 1d) in which lower-force unfolding peaks are ...
and gelsolin, somewhat like the interaction between antibody and antigen, would be applicable to fabricate a novel electrochemical immunoassay for the detection of total amount of Aβ 1–40 and Aβ 1–42 . Herein, on the basis of our previous work, we reported the design and evaluation of ...
Gelsolin, an actin-binding and severing protein present in many mammalian cells, was characterized in human testis. Although abundant in testicular extracts, gelsolin was not detected in purified spermatogenic cells by immunoblot analysis. Immunofluorescence studies of testis sections showed that gelsolin ...
Huang S, Blanchoin L, Chaudhry F, Franklin‐Tong VE, Staiger CJ (2004) A gelsolin‐like protein from Papaver rhoeas pollen (PrABP80) stimulates calcium‐regulated severing and depolymerization of actin filaments. J Biol Chem 279: 23364-23375...
Liu Z, Kanzawa N, Ono S (2011) Calcium-sensitive activity and conformation of Caenorhabditis elegans gelsolin-like protein 1 are altered by mutations in the first gelsolin-like domain. J Biol Chem 286: 34051-34059. doi: 10.1074/jbc.M111.237404 PMID: 21840993...