[Ca2+]i, indicating that gelsolin is activated in regions of high [Ca2+]isuch as near the channels of intracellular stores or subjacent to the cell membrane[148]. Gelsolin–actin complexes form transiently during Ca2+and spreading-inducedcell activation[160,161]. Activation is associated with ...
Define gelsolin. gelsolin synonyms, gelsolin pronunciation, gelsolin translation, English dictionary definition of gelsolin. n. A calcium-regulated actin-binding protein that breaks cytoskeletal actin filaments into smaller pieces, thus transforming the
The intestine is renewed approximately every 5 days and this renewal is controlled by ISCs [2, 3]. As the fundamental source of intestinal regeneration, ISCs are essential for intestinal regeneration after injury [4, 5]. ISCs, marked by several markers such as Lgr5 and OLFM4, are located ...
Homeodomain-interacting protein kinase-2 (HIPK2) is a positive regulator of p53 oncosuppressor function. Here, we show, by microarray analysis, that wtp53 lost the target gene activation following stable knockdown of HIPK2 (HIPK2i) in colon cancer cell line. Our data show that the stable ...
Gelsolin is a downstream effector of rac for fibroblast motility Rac, a member of the rho family of GTPases, when activated transmits signals leading to actin-based membrane ruffling in fibroblasts. Compared with wild-ty... T Azuma,W Witke,TP Stossel,... - 《Embo Journal》 被引量: 662...
Ca2+ regulation of gelsolin by its C-terminal tail Gelsolin is activated by Ca(2+) to sever actin filaments. Ca(2+) regulation is conferred on the N-terminal half by the C-terminal half. This paper seeks to... KM Lin,M Mejillano,HL Yin - 《Journal of Biological Chemistry》 被引量...
activated binding mechanism illustrated by others10,11,12,13. In our case, force only shifts the equilibrium between calcium-free and calcium-bound states. Even in the absence of force, a certain level of binding affinity is retained. In our experiments, we used the unfolding forces at ...
A dynamic actin cytoskeleton is essential for pollen germination and tube growth. However, the molecular mechanisms underlying the organization and turnove... H Zhang,X Qu,C Bao,... - 《Plant Cell》 被引量: 257发表: 2010年 Mapping the ADF/Cofilin Binding Site on Monomeric Actin by Competiti...
FIGURE 3. GzmB-cleaved gelsolin is activated and severs actin filaments in a Ca2+-independent manner in vitro. Globular actin was polymerized into F-actin by the addition of KCl, CaCl2, and ATP. After reaching the plateau (polymerized F-actin), the appropriate buffer, intact rec.c-gelsolin...
(FCs), which are at the origin of muscle fibres, harbour all the information required for individual muscle identity. This information is thought to be provided by the combinatorial expression of identity genes encoding identity transcription factors (iTFs)4,5. They are all activated in subsets ...