(end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Cellular_Location Isoform 2: Cytoplasm, cytoskeleton. Tissue_Location Phagocytic cells, platelets, fibroblasts, nonmuscle cells, ...
TrkA-III对NGF具有抗性,组成性地激活AKT1和NF-κB,不能激活Ras-MAPK信号级联。拮抗抗增殖的NGF-NTRK1信号,促进神经元前体分化。Isoform TrkA III促进血管生成,当过表达时具有致癌活性。 Subunit: 存在于单体(低亲和力)和二聚体(高亲和力)结构之间的动态平衡。同源二聚反应是由NGF二聚体的结合诱导的。与QSTM1交互...
The growing epidemic of the inflammation-related metabolic disease, type 2 diabetes mellitus, presents a challenge to improve our understanding of potential mechanisms or biomarkers to prevent or better control this age-associated disease. A gelsolin isoform is secreted into the plasma as part of the...
Gelsolin is a multi-functional Ca+2 dependent actin-regulating protein that circulates in healthy human plasma [1]. Gelsolin has 3 isoforms two of which are cytoplasmic and one is secretory extracellular plasma isoform. These are namely mature plasma (secretory) gelsolin (pGSN), cytoplasmic gelsoli...
The most extensively studied function of the c-gelsolin isoform is its actin filament modifying activity (13, 15). Ca2+ binding leads to a structural rearrangement in the NH2- and COOH-terminal halves of the molecule that allows severing and capping of actin (15). During Fas-mediated ...
After secondary antibody incubation, membranes were washed with TBST (3x; 15 min each). The protein bands were visualized using Enhanced chemiluminescent (ECL) kit (Thermofisher scientific) on ChemiDoc Imaging system (BioRad) and analyzed by measuring the densities of protein bands using Image J ...
Kent et al., A monoclonal antibody to alpha 4 integrin suppresses and reverses active experimental allergic encephalomyelitis. J Neuroimmunol. Apr. 1995;58(1):1-10. Kouyama et al., Fluorimetry study of N-(1-pyrenyl)iodoacetamide-labelled F-actin. Local structural change of actin protomer bot...