GAIN-of-function mutationsHUMAN experimentationCORONAVIRUS diseasesMERS coronavirusGain of function research is a little known and controversial area of study in virology. Though there is some disagreement in the exact definition of gain of function, the process involves modifying animal viruses to infect...
nonprofit over several years to study bat coronaviruses was "judged by qualified staff up and down the chain as not being gain-of-function," noting that many scientists believe the "government definition is too limited and can allow de facto gain-of-function research to bypass safety protocols...
Though gain-of-function research does not leave a physical marker to prove origin, to date, there is no evidence Covid was of a natural origin (this is surprising because both the SARS1 and MERS viruses [related to Covid] had left copious traces in the environment.) There is much to ...
These data demonstrate a gain of function associated with p53 mutations in addition to the loss of function shown previously to be associated with mutations in this tumour suppressor gene. This is a preview of subscription content, access via your institution Access options Subscription info for Ch...
Mutant p53 can attenuate the function of wild-type p53, p63 and p73. An aggregation-nucleating sequence in p53 that is revealed in structurally destabilized mutants can induce coaggregation with p63 and p73, resulting in their sequestration in cellular i
Journal of Biomedical Science 2014, 21:40 http://www.jbiomedsci.com/content/21/1/40 RESEARCH Open Access Characterization of a new mouse p53 variant: loss-of-function and gain-of-function James Yi-Hsin Chan1,2, Ying-Chuan Chen3, Shu-Ting Liu3, Wei-Yuan Chou3*, Ching-Liang Ho4* ...
[37]. Conversely, altered E1B-19K function may have a role in the increased host inflammatory response seen in emerging, pathogenic HAdV strains. Further research and characterization of novel and re-emerging viruses are necessary to understand how gain- or loss-of-function mutations impact ...
Consequently, tracking filters for such systems have become an important area of research [26,27,28,29]. However, almost all conventional position-velocity-measured (PVM) trackers have been based on Kalman or particle filtering, whereas fixed-gain PVM filters have not seen wide use. This is ...
Antenna gain is the measure of how effectively an antenna can concentrate and transmit signals in specific directions, and it can be approximated using the half-power beam-widths measured in the two principal planes. AI generated definition based on: Reference Data for Engineers (Ninth Edition), ...
Immunosuppression has become a research hotspot in tumors to escape immune treatment [40]. Furthermore, overexpressing PD-L1 will allow tumors to escape the effector-immune responses [38]. Therefore, it is reasonable to study the critical function of the mutant p53 signaling pathway in cancer....