Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada Eric H. Ma & Russell G. Jones Department of Physiology, McGill University, Montreal, Quebec, Canada Eric H. Ma & Russell G. Jones Epigenomics Group, D-BSSE, Eidgenössische Technische Hochschule, Basel, Switzerland Marc...
We study the stochastic dynamics of the two most common patterns in cancer initiation and progression: loss-of-function and gain-of-function mutations. We consider three stochastic models of cell populations with a constant size: a mass-action model, a spatial model and a hierarchical model. For...
Here, we show that transgenic expression of Sox10, a close relative of Sox9, in gonads of XX mice resulted in development of testes and male physiology. The degree of sex reversal correlated with levels of Sox10 expression in different transgenic lines. Sox10 was expressed at low levels in...
Apart from that, there is accumulating evidence of the important role of GlyRs in cerebellar structures in development of neural pathologies such as hyperekplexia, which can be triggered by GlyR gain‐of‐function mutations. In this research we initially tested functional properties of GlyRs, ...
D. A Ras-dependent chloride current activated by adrenocorticotropin in rat adrenal zona glomerulosa cells. Endocrinology 141, 684–692 (2000). Article PubMed Google Scholar Jentsch, T. J. Discovery of CLC transport proteins: cloning, structure, function and pathophysiology. J. Physiol. 593, ...
Gain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway Fan Yang,1,2 Mo Xu,1 Shiqing Wang,1 Le Song,1 Dandan Yu,1 Yao Li,1 Rui Cao,1 Zhang Xiong,1,2 Zhijun Che
De novo gain of function mutations in GRIN2B encoding the GluN2B subunit of the N-methyl-d-aspartate (NMDA) receptor have been linked with epileptic encephalopathies, including infantile spasms. We investigated the effects of radiprodil, a selective GluN2B negative allosteric modulator and other ...
In research into cortical function, the use of general anaesthesia aims to prevent acute pain and reduce signal noise, while still leaving the sensory information pathway to the neocortex as intact as possible. Gold-standard studies in this field have therefore historically been performed under anaest...
OPEN Citation: Oncogenesis (2016) 5, e196; doi:10.1038/oncsis.2016.8 www.nature.com/oncsis REVIEW Gain of function of mutant p53: R282W on the peak? Y Zhang1, SV Coillie1,2, J-Y Fang1 and J Xu1 Mutant p53 proteins commonly lose their tumor suppression function and gain novel ...
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