In this clarifying matrix, 4 classes of threats are identified: pathogens of pandemic potential; pathogens of critical regional importance; bioterrorism, dual-use research of concern, and gain-of-function research of concern; and endemic diseases. Deadliest Enemy: Our War against Killer Germs Seipin...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook Mutation (redirected fromgain-of-function mutation) Dictionary Thesaurus Medical Legal 1.the act or process of mutating; change; alteration 2.a change in the chromosomes or genes of a cell. When this change occur...
Mutant p53 can attenuate the function of wild-type p53, p63 and p73. An aggregation-nucleating sequence in p53 that is revealed in structurally destabilized mutants can induce coaggregation with p63 and p73, resulting in their sequestration in cellular i
OPEN Citation: Oncogenesis (2016) 5, e196; doi:10.1038/oncsis.2016.8 www.nature.com/oncsis REVIEW Gain of function of mutant p53: R282W on the peak? Y Zhang1, SV Coillie1,2, J-Y Fang1 and J Xu1 Mutant p53 proteins commonly lose their tumor suppression function and gain novel ...
loss-of-function and gain-of-function James Yi-Hsin Chan1,2, Ying-Chuan Chen3, Shu-Ting Liu3, Wei-Yuan Chou3*, Ching-Liang Ho4* and Shih-Ming Huang3* Abstract Background: p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation ...
[37]. Conversely, altered E1B-19K function may have a role in the increased host inflammatory response seen in emerging, pathogenic HAdV strains. Further research and characterization of novel and re-emerging viruses are necessary to understand how gain- or loss-of-function mutations impact ...
A common gain-of-function LPL variant, LPLS447X, has favorable clinical features and involves a C → G base change at nucleotide 1595 of the LPL cDNA, along with a haplotype, which includes other non-coding SNPs. The mechanism for the LPL gain-in-function is not clear. LPL translation ...
- 《Schizophrenia Research》 被引量: 345发表: 2004年 Changing the inhibitory specificity and function of the proteinase inhibitor eglin c by site-directed mutagenesis: functional and structural investigation. Amino acids in the serine proteinase...
St. Anna Children’s Cancer Research Institute (CCRI), Vienna, Austria Daniel Mayr, Rico Chandra Ardy & Kaan Boztug Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada Meera Mehta, Jie Pan, Qi Li, Walter H. A. Kahr, Mathieu Lemaire, Chien-Yi Lu, Cong-Hui Guo, ...
Although the gain of function (GOF) of p53 mutants is well recognized, it remains unclear whether different p53 mutants share the same cofactors to induce GOFs. In a proteomic screen, we identified BACH1 as a cellular factor that recognizes the p53 DNA-binding domain depending on its mutation...