Prevalent p53 missense mutations abrogate its tumor suppressive function and lead to "gain-of-function" (GOF) that promotes cancer. Here we show that p53 GOF mutants bind t... J Zhu,MA Sammons,G Donahue,... - 《Nature》 被引量: 183发表: 2015年 Research Progress in Oncology. Highlighting...
Conclusions: Here we propose the possibility that gain-of-function mutations of Gαs interfere with signals in the microenvironment of permissive tissues and lead to a transversal neoplastic phenotype. Keywords: GNAS, Heterotrimeric Gs protein, Activating mutation, Neoplasm, McCune Albright Syndrome, ...
These data demonstrate a gain of function associated with p53 mutations in addition to the loss of function shown previously to be associated with mutations in this tumour suppressor gene. This is a preview of subscription content, access via your institution Access options Subscription info for Ch...
Although the gain of function (GOF) of p53 mutants is well recognized, it remains unclear whether different p53 mutants share the same cofactors to induce GOFs. In a proteomic screen, we identified BACH1 as a cellular factor that recognizes the p53 DNA-b
A majority of voters support medical study known as gain of function research, a new Hill-HarrisX poll finds.Sixty-seven percent of registered voters in a June 29-30 survey said they would rather medical research continue to work with viru...
While there has been much focus on how mutations can disrupt protein structure and thus cause a loss of function (LOF), alternative mechanisms, specifically dominant-negative (DN) and gain-of-function (GOF) effects, are less understood. Here, we investigate the protein-level effects of ...
Recently, PDR1 gain-of-function (GOF) mutations have been shown to not only increase azole resistance but also enhance adherence during C. glabrata infection. However, mechanism of how Pdr1 regulates adherence, especially the implication of PDR1 GOF mutations in the regulation of the major ...
2.1 Sense of Economic Gain and Determinants Sense of economic gain is the primary outcome variable that this paper is concerned with. Research on the definition and indicators of the “sense of gain” among the populace rem...
of-function (GOF), which actively drive cells toward invasion and metastasis7 through transactivation or transrepression of a large set of genes involved in regulation of cell adhesion, migration and proliferation.8 In agreement with these findings, previous studies have found that overexpression of ...
Thus, a gain-of-function rare polymorphism in hGDH2 hastens the onset of PD in hemizygous subjects, probably by damaging nigral cells through enhanced glutamate oxidative dehydrogenation. The lack of effect in female heterozygous PD patients could be related to a modification of the overactive ...