1型糖尿病(Type 1 diabetes mellitus,T1DM)又称自身免疫相关糖尿病(或胰岛素依赖型糖尿病),是一种由于胰腺β细胞缺失导致胰岛素水平持续下降(或完全丧失),并最终表现为以高血糖症为典型临床表现的慢性代谢性疾病。 T1DM是儿童和青少年人群中比较常见的内分泌和代谢相关的疾...
GAD属于抑制性神经递质γ-氨基丁酸(gamma-aminobutyric acid,GABA)合成限速酶,GAD抗体在1988年被最早描述,是第一个被确认的突触蛋白抗体,其存在于多种神经系统疾病和1型糖尿病(type 1 diabetes mellitus,T1DM)。随后,越来越多的靶向细胞内和细胞...
Jun. 2000. Has GAD a central role in type 1 diabetes? J. Autoimmun. 15 :273–278.Yon J W,Sherwin R S,Kwon H.et口1.Has GAD a central role in type 1 diabetes[J].J Autoimmun,2000,15 (3):273--278.Yoon JW, Sherwin RS, Kwon H, Jun HS. Has GAD a central role in type 1 ...
是谷氨酸脱羧酶（glutamic acid decarboxylase，GAD）的缩写。GAD属于抑制性神经递质γ-氨基丁酸（gamma-aminobutyric acid，GABA）合成限速酶，GAD抗体在1988年被最早描述，是第一个被确认的突触蛋白抗体，其存在于多种神经系统疾病和1型糖尿病（type 1 diabetes mellitus，T1DM）。随后，越来越多的靶向细胞...
参考文献: Lohmann T, Hawa M, Leslie R D G, et al. Immune reactivity to glutamic acid decarboxylase 65 in stiffman syndrome and type 1 diabetes mellitus.[J]. Lancet, 2000, 356(9223):31-35.
［摘要］目的探讨I型糖尿病(type1diabetes mellitus,T1DM)患者血清谷胱氨酸脱竣酶抗体(glutamic acid decarboxylase antibody,GAD)、胰岛细胞自身抗体(islet cell autoantibody,ICA)、C肽(C-peptide,C-P)水平变化对T1DM患者的临床诊断价值。方法回顾性分析楚雄彝族自治州人民医院2019年1月至2020年8月期间54例T1DM确诊...
Fukui M,Nakamura N,Nakano K,et al.Cellular immune response to GAD in type 1 diabetes with residualβ-cell function[J].Diabetes Care,1999,22:1758.Fukui M,Nakamura N,Nakano K,et al Cellular immune response to GAD in type 1 diabetes with residualβ cell function〔J〕 Diabetes Care,1999;...
Prevalence of autoantibodies against IA-2 (IA-2A), glutamic acid decarboxylase (GADA), and type II DNA topoisomerase (TopIIA) of Taiwanese type 1 diabetes mellitus (T1DM) patients was investigated. Correlations of these autoantibodies with patients’ clinical manifestations were also analyzed. Prevale...
BackgroundThis study aimed to analyse data from two different studies (phase II and phase III) regarding the safety and efficacy of treatment with alum formulated glutamic acid decarboxylase GAD65 (GAD-alum) at 30months after administration to children and adolescents with type 1 diabetes.MethodsThe...
Thus, the prevalence of positive lymphoproliferative response to GAD in type 1 diabetic patients studied was higher than the prevalence of other autoimmune markers previously reported in type 1 diabetic patients in Thailand. 展开 关键词: GAD β-Casein Lymphoproliferation Type 1 diabetes ...