OBJECTIVE--To evaluate the significance of GAD antibodies (GADAs) and family history for type 1 diabetes (FH[sub T1]) or type 2 diabetes (FH[sub T2]) in nondiabetic subjects. RESEARCH DESIGN AND METHODS--GADAs were analyzed in 4,976 nondiabetic relatives of type 2 diabetic patients or ...
概述 GAD属于抑制性神经递质γ-氨基丁酸(gamma-aminobutyric acid,GABA)合成限速酶,GAD抗体在1988年被最早描述,是第一个被确认的突触蛋白抗体,其存在于多种神经系统疾病和1型糖尿病(type 1 diabetes mellitus,T1DM)。随后,越来越多的靶向细胞内和细胞表面蛋...
The prevalence of thyroid autoantibodies in dermatitis herpetiformis SUMMARYThe prevalence of IgG class thyroglobulin and microsomal antibodies, estimated using a sensitive ELISA, was 48% in 115 patients with dermatitis herpetiformis, which was significantly greater than the prevalence of 16% in 107 unsel...
Prevalence of LADA and frequency of GAD antibodies in diabetic patients with end-stage renal disease and dialysis treatment in AustriaThe prevalence of individuals with latent autoimmune diabetes in adults (LADA) among diabetic patients with... G Biesenbach,M Auinger,M Clodi,... - 《Nephrology Di...
GAD属于抑制性神经递质γ-氨基丁酸(gamma-aminobutyric acid,GABA)合成限速酶,GAD抗体在1988年被最早描述,是第一个被确认的突触蛋白抗体,其存在于多种神经系统疾病和1型糖尿病(type 1 diabetes mellitus,T1DM)。随后,越来越多的靶向细胞内和细胞表面蛋白以及兴奋性和抑制性突触受体的抗体被确定为中枢神经系统(central...
Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies Lancet (1974) D.B Jones et al. Heat-shock protein 65 as a B-cell antigen of insulin-dependent diabetes Lancet (1990) M Pietropaolo et al. Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ...
diagnosis (<0.01), thus identifying a substantial proportion of patients requiring insulin therapy within the first 2 years after the diagnosis of type 2 diabetes. Determination of GAD 65 antibodies in patients with late-onset diabetes may contribute to their correct classification and adequate ...
During the admission period, he was found to have anti-GAD and JA-2 antibodies indicating that he was suffered from type 1 diabetes. We report this case because the occurence of type 1 diabetes with ITP is considered to be relatively rare....
Antibodies to oxidized insulin improve prediction of type 1 diabetes in children with positive standard islet autoantibodies. Antibodies to posttranslationally modified insulin (oxPTM-INS-Ab) are a novel biomarker of type 1 diabetes (T1D). Here, we evaluated whether oxPTM-INS-Ab c... Rocky,St...
body;Diabetesmellitus 本研究旨在探讨酪氨酸磷酸酶抗体(IA-2Ab),谷氨酸脱 羧酶抗体(GAD—Ab),胰岛素自身抗体(IAA)联合检测对糖 尿病分型的诊断价值. 一 ,对象与方法 1.研究对象:我院的糖尿病患者(符合1999年WHO糖 尿病诊断标准),其中1型糖尿病(T1DM)46例,年龄23.4± ...