Type 1 diabetesIn vitro cell mediated reactivity to Glutamic Acid Decarboxylase (GAD) has been reported in man and in the non-obese diabetic (NOD) mouse. The demonstration of such reactivity in vivo using GAD in a simple intradermal skin test would be useful for mass screening of subjects at...
山西医科大学 硕士学位论文 脂联素球状结构域(gAd)改善3T3-L1脂肪细胞胰岛素抵抗的效 果与机制研究 姓名:*** 申请学位级别:硕士 专业:内分泌学 指导教师:**;王彦 20110425 山西医科大学硕士学位论文 脂联素球状结构域(gAd)改善3T3.L1脂肪细胞 胰岛素抵抗的效果与机制研究 中文摘要 目的 探讨脂联素球状结构域(globular...
Up to the present only few data have been available concerning the prevalence of diabetes-specific autoantibodies (anti-GAD, ICA, IAA, IA-2) in unselected populations, in particular in type 2 diabetic patients. Hence, the aim of the present study was to determine the prevalence of anti-GAD ...
Latent autoimmune diabetes in adults (LADA) accounts for 2%-12% of all cases of diabetes. Patients are typically diagnosed in young adults and are often misdiagnosed as type II DM. The aim is to study the association of GAD-65 autoantibodies as a marker in the diagnosis of LADA and to ...
成人隐匿性自身免疫性糖尿病(latent autoim-mune diabetes mellitus in adults,LADA)是1型糖尿 作者简介:秦雪鸽，女，主管技师，医学学士，研究方向：胰岛素抗体研究。E-mail：qinxuege6838@163.com ［本文引用格式］秦雪鸽，马斌，关慷慷，等.ICA、GAD-Ab、IAA联合检测在成人隐匿性自身免疫性糖尿病诊断中的 应用...
Another study reported that IA-2A improved test sensitivity in Japanese type 1 diabetes before puberty (<12 years) and the IA-2A frequencies steadily decreased with patient age [26]. IA-2A positivity was also reported to persist up to one year after diagnosis but Acknowledgements The work was...
pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct...
本发明涉及医疗诊断技术领域,公开了一种GAD65自身抗体检测试剂盒及其制备方法。本发明所述试剂盒包括GAD65抗原包被的超顺磁性纳米颗粒溶液、化学发光酶标记的抗人IgG单克隆抗体、稀释液、洗涤液和发光液。本发明试剂盒基于辉光型酶促化学发光方法进行间接法检测,对检测仪器要求相对较低,相比双抗原夹心法,具有更低的试剂...
which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. The two isoforms appear to have distinct intraneuronal distribution in the brain. GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS), IDDM...
The DEMEDITEC GAD autoantibody assay kit is intended for use by professional persons only, for the quantitative determination of GAD autoantibodies (GAD Ab) in human serum. Autoantibodies to pancreatic beta cell antigens are important serological markers of type 1 diabetes mellitus. The antigens recog...