这种用于碘离子测定的双模策略以其成本效益、简单性、高灵敏度(0.5 nmol/L)、稳定性和显著的选择性而脱颖而出。 Hemin可与G4(TGG GTA GGG CGG G)自组装形成具有较强过氧化物酶活性的G4/Hemin。此外,I-和G4/Hemin都能催化H2O2将...
atypical G-tract which includes a mismatched or a bulging non-guanine nucleotide, and a single loop of extreme size benefits the overall prediction.The python code may be found at http://github.com/odoluca/G4Catchall and the web application at http://homes.ieu.edu.tr/odoluca/G4Catchall...
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In addition, the conformational properties of G4 are largely influenced by the environmental conditions, in particular by the presence of monovalent ions such as K+ or Na+. These features grant high degree of polymorphism to G4 arrangements and make them suitable to differential recognition. In ...
Shankar Balasubramanian and colleagues examine endogenous DNA G-quadruplex (G4) structures in the context of chromatin by using G4 antibody-based ChIP–seq. They find that G4 structures are enriched in nucleosome-depleted regions and the promoters and 5
6796Accesses 25Altmetric Metrics Abstract Despite the demonstrated importance of DNA G-quadruplexes (G4s) in health and disease, technologies to readily manipulate specific G4 folding for functional analysis and therapeutic purposes are lacking. Here we employ G4-stabilizing protein/ligand in conjunction...
There are over 700,000 putative G4-quadruplexes (G4Qs) in the human genome, found largely in promoter regions, telomeres, and other regions of high regulation. Growing evidence links their presence to functionality in various cellular processes, where cellular proteins interact with them, either ...
Genome-wide surveys based on a quadruplex folding rule have been performed, which have identified 376,000 Putative Quadruplex Sequences (PQS) in the human genome, although not all of these probably form in vivo.[3] A similar study has identified putative G-quadruplexes in prokaryotes[4].There...
G-quadruplex (G4) is a four-stranded helical DNA secondary structure formed by guanine-rich sequence folding, and G4 has been computationally predicted to exist in a wide range of species. Substantial evidence has supported the formation of endogenous G4
Mgs1 binding to G4 motifs in vivo is partially dependent on the helicase Pif1. Pif1 is the major G4-unwinding helicase in S. cerevisiae . In the absence of Mgs1, we determined elevated gross chromosomal rearrangement (GCR) rates in yeast, similar to Pif1 deletion. Here, we highlight ...