The database of the experimentally identified DNA G-quadruplex sequences can be accessed athttp://tubic.tju.edu.cn/g4bank/.doi:10.1007/s12539-023-00577-9Hong-Sheng ZhongMeijing DongFeng GaoSpringer Nature SingaporeInterdisciplinary Sciences: Computational Life Sciences...
Here I explore the plethora of G-quadruplex DNA structures,and discuss their possible biological functions as well as the proteins thatinteract with them. Key words: c-myc/G-quartet/G4-DNA/Oncogene/ Telomere/Tetraplex.为了具有一定的功能,核酸需要采用特有的空间结构。长期以来,DNA被视为一种顽固的...
根据G4序列特征填写如下信息,相关参数网页中有详细介绍。Fill the blank according to the sequence features, and the related parameters are introduced in detail on the website. DDDD represents a tetrameric G-quadruplex formed by four DNA strands. 得到结果,可以在图中窗口旋转查看。Get the result, whic...
G-quadruplex (G4) is a four-stranded helical DNA secondary structure formed by guanine-rich sequence folding, and G4 has been computationally predicted to exist in a wide range of species. Substantial evidence has supported the formation of endogenous G4 (eG4) in living cells and revealed it...
关键词:G-四链体;转录调节;DNA复制;基因组稳定 Biological functions of G-quadruplex in genome PAN Haichen, XUE Hongyue, XU Ya'nan* (College of Life Sciences and Food Engineering, Inner Mongolia Minzu University, Tongliao 028000, China) Abstract: G-quadruplex (G4), one of non-canonical DNA ...
随着生物信息学和高通量测序等技术的发展,目前已经可以分析并鉴定基因组或转录组中的 G4s可 形成序列(putative quadruplex-forming sequence,PQS)。根据目前已有的技术,已发现数千个 G4s 广泛存在于各种生物的基因组调节区和 RNA ...
关键词:G-四链体;转录调节;DNA复制;基因组稳定 Biological functions of G-quadruplex in genome PAN Haichen, XUE Hongyue, XU Ya'nan* (College of Life Sciences and Food Engineering, Inner Mongolia Minzu University, Tongliao 028000, China) Abstract: G-quadruplex (G4), one of non-canonical DNA ...
G四联体(G-Quadruplex , G4)是通过四个鸟嘌呤之间的Hoogsteen氢键连接在一起的四链核酸二级结构。G4在基因组、转录组和端粒中均有存在,意味着G4具有重要的生物学功能,包括调控复制、转录、翻译、端粒形态维持等等。G4相关蛋白(G4-rela...
DNA G-quadruplexes (G4s) are non-canonical, four-stranded nucleic acid structures that comprise stacked G-tetrads within certain G-rich sequences (Fig.1a)14,15. DNA G4s have been shown to exist in human cells16,17,18, and their formation is dynamic in live cells19. G4 sequencing (G...
Nucleic acid sequences which are rich in guanine are capable of forming four-stranded structures called G-quadruplexes (also known as G-tetrads or G4-DNA). These consist of a square arrangement of guanines (a tetrad), stabilized by Hoogsteen hydrogen bonding. They are further stabilized by ...