(2013) Identification of G protein-coupled receptor signaling pathway proteins in marine diatoms using comparative genomics . BMC Genomics 14 :503.Port J.A., Parker M.S., Kodner R.B., et al. (2013) Identification of G protein-coupled receptor signaling pathway proteins in marine diatoms ...
G protein-coupled receptors (GPCRs) constitute a large family of receptors that activate intracellular signaling pathways upon detecting specific extracellular ligands. While many aspects of GPCR signaling have been uncovered through decades of studies,
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling 热度: G-protein coupled receptor (GPCR) signaling (Morgan Sheng) 热度: nature19312-The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6 ...
Structural insights into the regulation of monomeric and dimeric apelin receptor The apelin receptor (APJR) is a drug target for cardiovascular and metabolic health. Here, authors reveal how ligand binding, receptor dimerization, and G protein coupling cooperate to regulate APJR signaling pathway, pro...
G-Protein Coupled Receptor 83 (GPR83) Signaling Determined by Constitutive and Zinc(II)-Induced Activity.doi:10.1371/journal.pone.0053347The G-protein coupled receptor 83 (GPR83) is an orphan G-protein coupled receptor for which the natural ligand(s) and signaling pathway(s) remain to be ...
Furthermore, GPCRs couple to non-G protein transducers, including β-arrestins or other scaffold proteins, to initiate additional signaling cascades. Receptor/transducer selectivity is dictated by agonist-induced receptor conformations as well as by collateral factors. In particular, ligands ...
In short, it is becoming increasingly clear that a number of non-receptor tyrosine kinases and tyrosine kinase receptors can link GPCRs to the Ras-MAPK pathway. However, the relative contribution of each of these kinases in GPCR signaling to MAPK is still unclear and under current investigation...
Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein
The Hedgehog (Hh) signaling pathway plays an essential role in vertebrate embryonic tissue patterning of many developing organs. Signaling occurs predominantly in primary cilia and is initiated by the entry of the G protein-coupled receptor (GPCR)-like protein Smoothened into cilia and culminates in...
J. et al. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1α. J. Biol. ...