G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway. Acta Biochim Biophys Sin, 2015, 47(1): 10-15.Zhou X, Wang Z, Huang W, et al. G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway. Acta ...
趋化因子受体(C X C chemokine receptor 4,CXCR4)是一个具有7次跨膜结构的G蛋白耦联受体(G Protein-Coupled Receptor,GPCR),由352个氨基酸组成,其编码基因位于染色体2q21 [1-2]。CXCR4作为GPCR家族中的一员,GPCR的超家族群已经被证明是许多药物的药理作用靶点(点击查看GPCR抗体药物研究进展大盘点)。CXCR4在体内...
G-protein coupled receptors (GPCRs) are also popular as an integral membrane protein receptor that are being used by cells to convert extracellular signals into intracellular responses.5,7This includes responses to hormones, vision, olfaction, taste, neurotransmitters, etc. GPCRs form a superfamily ...
G protein-coupled receptor kinases(GRKs) are key modulators of G protein-coupled receptor signalling. Increasing evidence points to the occurrence of complex mechanisms able to modulate the subcellular localization, activity and expression levels of GRKs, revealing new functional interactions of...
G protein-coupled receptors (GPCRs) constitute a large family of receptors that activate intracellular signaling pathways upon detecting specific extracellular ligands. While many aspects of GPCR signaling have been uncovered through decades of studies, some fundamental properties, like its channel capacity...
G蛋白偶联的信号传导系统由G蛋白偶联受 protein coupled recptors 即 GPRs)、G蛋白和效应器(Effector)分子组成。G蛋白是一个分子开关,传导由GPRs接收的信号,再以G蛋白解离亚基作为传导物,活化相应酶和离子通道,产生重要的第二信使,从而引起胞内相应的生物反应。当牧民的活化剂存在时,活化的受体激活特异的G蛋白,催化...
G protein-coupled receptor 30 (also known as G protein-coupled oestrogen receptor) mediates rapid effects induced by oestrogens and anti-oestrogens in boths normal and cancer cells. Overexpression of this receptor has been associated with negative clinical features and poor survival rates in patients...
G蛋白偶联受体49(GPR49)又称GPR67或LGR5,是肠上皮和毛囊的干细胞标记物。GPR49是Wnt信号通路的靶点。GPR49在骨骼肌、胎盘、脊髓和脑的不同区域均有表达。 别名Alternate Names: Leucine-rich repeat-containing G-protein coupled receptor 5; Orphan G-protein coupled receptor HG38; G-protein coupled receptor...
G蛋白偶联受体75(G-protein-coupled receptor 75, GPR75)是G蛋白偶联受体(G-protein-coupled receptors, GPCRs)家族一员,发现以来一直被列为孤儿受体[3]。在人血管内皮细胞及大鼠主动脉平滑肌细胞中的研究中发现,20-HETE与GPR75具...
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors Transduction of a mitogenic signal from the cell membrane to the nucleus involves the adapter proteins SHC and Grb2, which mediate activation of the Ras/mitogen-activated protein (MAP) kinase pathway. In contr...