Insights into the G-protein coupled receptor pathway of Tetrahymena thermophila.Tetrahymena thermophila is a model organism for cellular chemosensory research. Many chemical signals such as chemoattractants, chemorepellents, and neurotransmitters are detected by G-protein coupled receptors (GPCRs) on ...
A method to study G-protein-coupled receptor (GPCR) trafficking has been developed using engineered APEX2 and CRISPR interference screening. The innovative approach reveals a network of proteins coordinated by DNAJC13 that control efficient GPCR sorting into degradative or recycling pathways. ...
G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Mol. Biol. Cell 17, 667–679 (2006). Article CAS PubMed PubMed Central Google Scholar Brown, N. A. et al. G-protein coupled receptor-mediated nutrient sensing and developmental...
G蛋白偶联受体75(G-protein-coupled receptor 75, GPR75)是G蛋白偶联受体(G-protein-coupled receptors, GPCRs)家族一员,发现以来一直被列为孤儿受体[3]。在人血管内皮细胞及大鼠主动脉平滑肌细胞中的研究中发现,20-HETE与GPR75具...
Human herpesvirus KSHV encodes a constitutively active G-protein- coupled receptor linked to cell proliferation. Nature 385, 347–350. (1997). Article CAS PubMed Google Scholar Sodhi, A. et al. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-...
Proliferative Signaling through G Protein-coupled Receptors Role of MAP Kinase in Proliferative Pathways Signaling from G Protein-coupled Receptors to MAP Kinase Involves βγ Subunits of Heterotrimeric G Proteins Acting on a Ras-dependent Pathway The Pathway Linking GPCRs and Gβγ to Ras: Tyrosine...
G-protein coupled receptor regulation pathway; GPCR downstream effectors; functional characterization; insect physiology; insecticide resistance; cell lines1. Introduction G-protein-coupled receptors (GPCRs), which are proteins sharing a seven α-helical transmembrane structure, govern a number of ...
G Protein Coupled Receptor Families Rhodopsin familySecretin/glucagon receptor familyGlutamate receptor/calcium sensor family Receptor for amine neurotransmitters, peptide, purines, prostanoids Receptor for peptide hormones, secretin, glucagon GABAB receptors, Ca2+–sensing receptors Short EC tail,...
OPEN A G-protein-coupled receptor regulation pathway in cytochrome Figure 1. Cytochrome P450 genes in HAmCqG8 or MAmCqG6 associated with permethrin resistance.(A) mRNA levels of different P450 genes (up-regulated CYP9M10, CYP6AA7, CYP9J34, CYP9J40, or non-up-regulated CYP6BY3 in ...
et al. A G-protein-coupled receptor regulation pathway in cytochrome P450-mediated permethrin-resistance in mosquitoes, Culex quinquefasciatus. Sci. Rep. 5, 17772; doi: 10.1038/srep17772 (2015). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or...