G protein-coupled receptors (GPCRs) are among the best-studiedmembrane receptors, mainly due to their central role in human physiology, involvement in disease and relevance as drug targets. Although biochemical and pharmacological studies have characterized the main steps in GPCR signaling, how...
近日,来自宁夏医科大学的研究者们在Signal Transduction and Targeted Therapy杂志上发表了题为“G protein-coupled receptors (GPCRs): advances in structures,mechanisms, and drug discovery”的综述性文章,该研究揭示了G蛋白偶联受体的结构、机制和药物发现的进展。 G蛋白偶联受体(gpcr)是最大的人膜蛋白家族,也是一...
All these steps represent potential regulatory checkpoints and possible targets for therapeutic intervention. Cell surface receptors include G protein-coupled receptors (GPCRs), as well as, ion channels and enzyme-linked receptors. GPCRs are responsible for physiological responses as diverse as visual ...
近日,来自宁夏医科大学的研究者们在Signal Transduction and Targeted Therapy杂志上发表了题为“G protein-coupled receptors (GPCRs): advances in structures,mechanisms, and drug discovery”的综述性文章,该研究揭示了G蛋白偶联受体的结构、机制和药物发现的进展。
Targeting G protein-coupled receptors (GPCRs) in metabolic tissues — such as adipose tissue, liver, muscle, pancreatic islets, immune cells and the central nervous system — has emerged as a key target for current and future anti-diabetic compounds. This Opinion focuses on the potential of ...
《G Protein-Coupled Receptors in Health and Disease》是2009年出版的 图书，作者是Tao, Ya-Xiong 。内容简介 G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. ...
G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors in the mammalian genome. They are activated by a multitude of different ligands that elicit rapid intracellular responses to regulate cell function. Unsurprisingly, a large proportion of therapeutic agents target these...
G-protein signalling pathways are involved in sensing the environment, enabling fungi to coordinate cell function, metabolism and development with their surroundings, thereby promoting their survival, propagation and virulence. G-protein-coupled receptors (GPCRs) are the largest class of cell surface rec...
G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have ...