Receptors, G-Protein-CoupledSignal TransductionStress, PhysiologicalCell CycleArabidopsis ProteinsGprotein-coupled receptors are now defined in molecular terms and rightly so. Their most salient characteristic is the possession of a number of structural motifs the most important of which is the ...
Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs). GPCRs act on inactive Gα·GDP/Gβγ heterotrimers to promote GDP release and GTP binding, resulting in liberation of Gα from Gβγ. Gα·GTP and Gβγ target effectors including adenylyl cyclases,...
Cell surface receptors belonging to the family of G protein coupled receptors (GPCRs) – also known as seven-transmembrane, heptahelical or serpentine, receptors – are involved in the regulation of diverse signaling processes. Heterotrimeric G proteins, consisting of α, β, and γ-subunits ...
Proteases, like thrombin, trypsin, cathepsins, or tryptase, can signal to cells by cleaving in a specific manner, a family of G protein-coupled receptors, the protease-activated receptors (PARs). Proteases cleave the extracellular N-terminal domain of PARs to reveal tethered ligand domains that ...
Also, the findings in many cellular systems of significant cross-talk between signaling pathways provide an impetus to examine how signaling through G protein–coupled receptors (GPCRs) might impinge on signaling through Fc, antigen, or cytokine receptors. This review focuses on the known and ...
G protein-coupled receptors (GPCRs) constitute a large family of receptors that activate intracellular signaling pathways upon detecting specific extracellular ligands. While many aspects of GPCR signaling have been uncovered through decades of studies, some fundamental properties, like its channel capacity...
G protein-coupled receptors and signaling pathways regulating growth responses FASEB, J 10 (1996), pp. 741-749 Google Scholar Prézeau et al. 1996 L Prézeau, J Gomeza, S Ahern, et al. Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing genera...
BRUCE G. ALLENTERENCE E. HBERTtaylorJ Recept Signal Transduct ResB. Boivin, G. Vaniotis, B.G. Allen, T.E. Hebert, G protein-coupled receptors in and on the cell nucleus: a new signaling paradigm?, J Recept. Signal Transduct. Res. 28 (2008) 15-28, http://dx.doi.org/10.1080/...
Platelet G protein-coupled receptors (GPCRs) initiate and reinforce platelet activation and thrombus formation. The clinical utility of antagonists of the P2Y(12) receptor for ADP suggests that other GPCRs and their intracellular signaling pathways may represent viable targets for novel antiplatelet agen...
G protein-coupled receptor kinases (GRKs) constitute a family of seven serine/threonine protein kinases that specifically phosphorylate agonist-activated G protein-coupled receptors (GPCRs). Receptor phosphorylation triggers the binding of cytoplasmic β-arrestin molecules, which sterically block interaction...