Signaling by Nuclear ReceptorsThe Signaling Pathway of the Steroid Hormone ReceptorsSignaling by Retinoids, Vitamin D3, and the T3-Hormone Structure of the HREs of RXR HeterodimersComplexity of the Interaction between HRE, Receptor and Hormone DNA-Binding Elements of Nuclear Receptors, HREsThe DNA-...
G protein-coupled receptors (GPCRs) constitute a large family of receptors that activate intracellular signaling pathways upon detecting specific extracellular ligands. While many aspects of GPCR signaling have been uncovered through decades of studies, some fundamental properties, like its channel capacity...
A method to study G-protein-coupled receptor (GPCR) trafficking has been developed using engineered APEX2 and CRISPR interference screening. The innovative approach reveals a network of proteins coordinated by DNAJC13 that control efficient GPCR sorting into degradative or recycling pathways. ...
Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners...
G Protein Coupled Receptor 30 (GPR30) is a novel receptor that can be found intracellularly in the endoplasmic reticulum or cell nucleus, depending on the species and cell type. It is involved in signaling pathways that can lead to both nongenomic and direct genomic effects, such as the acti...
This is the third article of three in the “Signaling by Heterotrimeric G Proteins Minireview Series.” 1 The abbreviations used are: GPCR, G protein-coupled receptor; PIP2, phosphatidylinositol bisphosphate; MAP, mitogen-activated protein; ERK, extracellular signal-regulated kinase; MAPK, mitogen-...
This study explores the role of G-protein-coupled receptor-intracellular signaling in the development of P450-mediated insecticide resistance in mosquitoes... T Li,N Liu - 《Biochemistry & Biophysics Reports》 被引量: 5发表: 2017年 OPEN A G-protein-coupled receptor regulation pathway in cytochrome...
Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential sig... The biological and biochemical effects of estrogen have been ascribed to its known receptors, which function as ligand-inducible transcription ...
Taste receptor cells are responsible for transducing chemical stimuli from the environment and relaying information to the nervous system. Bitter, sweet and umami stimuli utilize G-protein coupled receptors which activate the phospholipase C (PLC) signaling pathway in Type II taste cells. However, it...
G protein-coupled receptors (GPCRs) mediate cellular responses to a myriad of hormones and neurotransmitters that play vital roles in the regulation of physiological processes such as blood pressure. In organs such as the artery and kidney, hormones or n