G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis- associated colorectal cancers[J]. Protein Cell, 2016, 7 (2) : 130-140.Li W, Zhang X, Chen Y, Xie Y, Liu J, Feng Q, Wang Y, Yuan W and Ma J: G‑CSF is a key ...
多项研究表明,G-CSF通过动员骨髓源性细胞(bone marrow–derived cells, BMDCs),刺激循环内皮祖细胞(circulating endothehelial progenitor cells, CEPs), Gr1+ CD11b+骨髓源性抑制细胞(myeloid-derived suppressor cells, MDSCs)和VEGF-1+的髓样造血细胞的活化、增殖,诱导血管形成及肿瘤增殖。 2005年Yuichi Ohki等...
骨髓源性抑制细胞(myeloid-derivedsuppressorcells,MDSCs)和VEGF-1 + 的髓样造血细胞的活化、增殖,诱导血管形成及肿瘤增殖。其中MDSCs是构成不良预后关键的一环。虽然G-CSF已经广泛应用于肿瘤相关白细胞下降的临床治疗,但G-CSF与肿瘤发生、发展的关系,与放化疗、靶向治疗联合应用的时机、剂量、作用机制及效果等还需要...
髓源性抑制细胞(MDSC)为一群不成熟的异质性髓细胞,通过不同的机制抑制固有与获得性免疫系统,并且参与多种病理过程,如炎症、肿瘤与自身免疫性疾病的发生等.MDSC在肿瘤进展与免疫逃逸中发挥重要作用.多项研究结果均表明,淋巴瘤、白血病等血液系统恶性疾病中MDSC数量增多,并且其扩增与不良预后相关.笔者拟就MDSC参与多种...
转录组分析表明,与C2和C3 mIDH1 TME中的水平相比,来自wtIDH1 TME的C7和来自mIDH1 TME(PMN-MDSCs)的C1中Fcgr3的水平最高。相比之下,Fcgr2b在任何簇之间都没有差异表达。髓系簇是浸润wtIDH1和mIDH1人类胶质瘤最丰富的免疫细胞。 GM-CSF、CXCL1、CXCL10、IL-5、巨噬细胞炎性蛋白2、IL-6和肿瘤坏死因子-ɑ...
However, the significance of tumor G-CSF expression and MDSC in the chemosensitivity of cervical cancer have never been investigated. In the current study, we examined the prognostic significance of tumor G-CSF expression in patients with recurrent or metastatic cervical cancer that had been treated...
Monocytes and myeloid derived suppressor cells (MDSC) have been implicated on the regulation of tumor growth. Histamine is also important for regulating MDSC responses. Oral administration of the H2 receptor antagonist ranitidine can inhibit breast tumor growth and metastasis. In the current study, we...
Using G-CSF loss- and gain-of-function approaches, we demonstrated for the first time that: 1) abrogating G-CSF production significantly diminished granulocytic MDSC accumulation and tumor growth; 2) ectopically over-expressing G-CSF in G-CSF-negative tumors significantly augmented granulocytic MDSC...
图11A-B.对体内肿瘤G-CSF生产的中和降低MDSC的频率和T细胞抑制能力。用工程化以表达人G-CSF的1×10 6 个MC38结肠癌细胞接种C57B1/6小鼠。7天后,每周用200μg抗G-CSF克隆1B11或3B3或同种型对照抗体治疗动物3次。A)在第25天,对动物实施安乐死并取出脾,并通过流式细胞术分析CD11b+Ly6G+细胞(MDSC)的存在...
在这些细胞类型中,CDllb+Grl+细胞在肿瘤中及在携带肿瘤的动物的外周血(PB)中频繁增多,而且显示出促进肿瘤血管发生(Yang et al. , Cancer Cell 6,409-421 Q004))及遏制免疫功能,因此命名为髓样衍生抑制细胞 (MDSC) (Bronte et al.,Blood 96:3838-3846(200))。然而,负责外周动员、肿瘤归巢、和 CDllb+...