G-CSF is a key mod- ulator of MDSC and could be a potential thera- peutic target in colitis-associated colorectal cancers. Protein Cell 2016; 7: 130-140.Li W, Zhang X, Chen Y, Xie Y, Liu J, Feng Q, et al. G-CSF is a key modulator of MDSC and could be a potential ...
多项研究表明,G-CSF通过动员骨髓源性细胞(bone marrow–derived cells, BMDCs),刺激循环内皮祖细胞(circulating endothehelial progenitor cells, CEPs), Gr1+ CD11b+骨髓源性抑制细胞(myeloid-derived suppressor cells, MDSCs)和VEGF-1+的髓样造血细胞的活化、增殖,诱导血管形成及肿瘤增殖。 2005年Yuichi Ohki等...
目的 探讨粒-巨噬细胞集落刺激因子(GM-CSF)对于人外周血单核细胞向髓系抑制性细胞(MDSCs)转化的影响,进而建立高效的体外诱导体系.方法 收集2017年1月至2017年3月肾移... 林哲闽,吉嘉伟,蒋一航,... - 《中华器官移植杂志》 被引量: 0发表: 2017年 MAGE-3/CEA(HLA-A2\\A24~+)肽疫苗诱导消化道肿瘤患...
Using G-CSF loss- and gain-of-function approaches, we demonstrated for the first time that: 1) abrogating G-CSF production significantly diminished granulocytic MDSC accumulation and tumor growth; 2) ectopically over-expressing G-CSF in G-CSF-negative tumors significantly augmented granulocytic MDSC...
在这些细胞类型中,CDllb+Grl+细胞在肿瘤中及在携带肿瘤的动物的外周血(PB)中频繁增多,而且显示出促进肿瘤血管发生(Yang et al. , Cancer Cell 6,409-421 Q004))及遏制免疫功能,因此命名为髓样衍生抑制细胞 (MDSC) (Bronte et al.,Blood 96:3838-3846(200))。然而,负责外周动员、肿瘤归巢、和 CDllb+...
Microglia Steady-State Markers Monocyte Markers Mouse Tissue-Resident Macrophage Markers Myeloid-derived Suppressor Cells (MDSC) Receptor Tyrosine Kinases (RTKs) in the Akt Pathway Receptors in the Jak/STAT Pathway SCF, Flt-3 Ligand and M-CSF...
Objective: To investigate the effect of granulocyte-colony stimulating factor (G-CSF) in vitro stimulation on the distribution of lymphocyte subset in healthy human. Methods: Peripheral blood mononuclear cells (PBMNCs) were collected from 8 healthy volunteers by density gradient centrifugation on Ficoll...
The source of hematopoietic stem cells (HSCs) for allogeneic transplantation has evolved over the last decades, from the sole use of unstimulated bone marrow (BM) to the use of G-CSF (filgrastim)-mobilized peripheral blood, G-CSF-primed BM (G-BM) and cor
(SDF-1)的表达情况;流式细胞术分别检测G-CSF作用于结肠癌肺转移小鼠后外周血和脾脏中MDSCs的细胞比例.5.将BALB/c小鼠随机分为肺转移组,L-OHP干预后肺转移组,肠胃清联合化疗药物干预后肺转移组,化疗药物联合抗G-CSF治疗组.分别给予四组小鼠腹腔注射L-OHP15mg/kg,中药复方肠胃清灌胃以及腹腔注射G-CSF-Mouse-...
Clinical samples, cervical cancer cell lines, and a mouse model of cervical cancer were employed to examine the mechanisms responsible for the development of chemoresistance in G-CSF-producing cervical cancer, focusing on myeloid-derived suppressor cells (MDSC). As a result, the tumor G-CSF ...