Granulocyte 刺激殖民地的因素(G-CSF ) 是嗜中性的 trafficking 的一个必要管理者并且高度在多重肿瘤被表示.Myeloid 导出 suppressor 房间(MDSC ) 由有免疫力的抑制通过多重机制支持肿瘤的前进.尽管有在结肠癌前进的 G-CSF 功能的调查结果, MDSC 规定上的 G-CSF 和它肿瘤生长上的封锁效果的精确机制仍然是调查的...
多项研究表明,G-CSF通过动员骨髓源性细胞(bone marrow–derived cells, BMDCs),刺激循环内皮祖细胞(circulating endothehelial progenitor cells, CEPs), Gr1+ CD11b+骨髓源性抑制细胞(myeloid-derived suppressor cells, MDSCs)和VEGF-1+的髓样造血细胞的活化、增殖,诱导血管形成及肿瘤增殖。 2005年Yuichi Ohki等...
Monocytes and myeloid derived suppressor cells (MDSC) have been implicated on the regulation of tumor growth. Histamine is also important for regulating MDSC responses. Oral administration of the H2 receptor antagonist ranitidine can inhibit breast tumor growth and metastasis. In the current study, we...
在这些细胞类型中,CDllb+Grl+细胞在肿瘤中及在携带肿瘤的动物的外周血(PB)中频繁增多,而且显示出促进肿瘤血管发生(Yang et al. , Cancer Cell 6,409-421 Q004))及遏制免疫功能,因此命名为髓样衍生抑制细胞 (MDSC) (Bronte et al.,Blood 96:3838-3846(200))。然而,负责外周动员、肿瘤归巢、和 CDllb+Gr...
However, the significance of tumor G-CSF expression and MDSC in the chemosensitivity of cervical cancer have never been investigated. In the current study, we examined the prognostic significance of tumor G-CSF expression in patients with recurrent or metastatic cervical cancer that had been treated...
that G-CSF could attenuate the reactivity of T and natural killer (NK) cells through inducing T helper 2 (Th2) cell polarization15, promoting the generation of regulatory T (Treg) cells16, tolerogenic dendritic cells (DCs)17,18 and possibly myeloid-derived suppressor cells (MDSCs)19,20,21...
肠胃清通过G-CSF-MDSCs途径抑制化疗后结肠癌肺转移的实验研究 目的:本论文旨在探讨化疗药物奥沙利铂(L-OHP)作用机体后,对机体内环境中粒细胞集落刺激因子(G-CSF)-髓源性抑制细胞(MDSCs)途径的影响,以及结肠癌肺转移的发生机制.并... 梁梦婷 - 上海中医药大学 被引量: 0发表: 2020年 ...
7,8,10 Accordingly, the presence of immunosuppressive LDNs, also known as granulocytic myeloid-derived suppressor cells (G-MDSCs), has been identified in the peripheral blood from patients with cancer,8,11, 12, 13 HIV-1 infections,14,15 sepsis,16 graft-versus-host disease,17 as well as ...
Using G-CSF loss- and gain-of-function approaches, we demonstrated for the first time that: 1) abrogating G-CSF production significantly diminished granulocytic MDSC accumulation and tumor growth; 2) ectopically over-expressing G-CSF in G-CSF-negative tumors significantly augmented granulocytic MDSC...
目的:探讨玄胡索散抑制乳腺癌小鼠脾脏髓源抑制细胞(MDSC)分化的作用机制.方法:4~5周龄BALB/c雌性小鼠48只,其中6只为正常对照组,其他42只采用小鼠左侧第二对乳腺皮下脂... 毛幼儿,刘曦,贺凯,... - 《浙江大学学报(医学版)》 被引量: 0发表: 2023年 益肾化痰方对乳腺癌骨转移模型小鼠血液PTHr P、TGF...