GLP-1R - cAMP signalling pathway in pancreatic beta cells. 另外一个可以激活 G_{as} 亚基的G蛋白耦联受体是TGR5——一种在肝脏具有高表达的胆汁酸受体。下图[4]中,TGR5与配体结合可以促进小肠内脂肪的吸收,且此机理受腺嘌呤环化酶/cAMP信号通路下调。 TGR5 signaling pathway via cAMP. G_{\alpha q/11}...
stimulation of Gαq/11 promotes sustained mTORC1 pathway activation and reversion of autophagy promoted by serum or amino acids removal. Gαq is present in autophagic compartments and lysosomes and is part of the mTORC1 multi-molecular complex, contributing to its assembly and activation via its ...
A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells. Proc Natl Acad Sci USA 1993; 90: 6741–6745. Article CAS PubMed PubMed Central Google Scholar Yang YM, Lee S, Nam CW, Ha JH, Jayaraman M, Dhanasekaran DN et al. G(alpha)...
5. Cao C, Huang X, Han Y, Wan Y, Birnbaumer L, Feng GS, Marshall J, Jiang M, Chu WM: Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway. Sci Signal 2009, 2:ra17.6. Liu YY, Chen MB, Cheng L, Zhang ZQ, Yu Z...
5. Cao C, Huang X, Han Y, Wan Y, Birnbaumer L, Feng GS, Marshall J, Jiang M, Chu WM: Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway.Sci Signal2009, ...
10. Lee C W, Park D J, Lee K H et al. Regulation of phospholipase C-beta 4 by ribonucleotides and the alpha subnuit of Gq, J Biol Chem, 1994,269:25335-25338 11. van Biesen T M, Luttrell L M, Hawes B E et al. Mitogenic sig-naling via G protein-coupled receptors, Endocr ...
The Schizosaccharomyces pombe glucose/cyclic AMP (cAMP) signaling pathway includes the Gpa2-Git5-Git11 heterotrimeric G protein, whose Gpa2 Galpha subunit ... FD Ivey,FX Taglia,F Yang,... - 《Eukaryotic Cell》 被引量: 24发表: 2010年 GTP酶激活蛋白MoGcs1参与调控稻瘟病菌的无性繁殖,附着胞...
1975. The Temperature Induction of Alpha-Linolenic Acid Synthesis in Cyanidium caldarium. Ph.D. Dissertation, Division of Biochemistry, University of Wyoming, Laramie. (3) + IX + 127 pp. (biochem., physiol.) Google Scholar Bedord, C.J. 1976. The temperature induction of alphalinolenic ...
G proteincoupled receptors (GPCRs) are a large family ofmembrane proteinsencoded by almost 800 human genes, and represent an important class of therapeutic targets[67,68].GPCRsare characterized by an extracellular N-terminus, seven transmembrane spanningalpha helices, and an intracellular C-t...
Expression of G protein alpha subunits in the retina.aImmunostaining of limGαq. White arrows indicate the signals in the rhabdomeric region of the eye.bFluorescence in situ hybridization with the antisense probe for limGαomRNA. Arrow heads indicate the positive signals in the cell body layer...