Divergent expression of alpha1-protease inhibitor genes in mouse and human. The alpha1-protease inhibitor proteins of laboratory mice are homologous in sequence and function to human alpha1-antitrypsin and are encoded by a highly c... T Jil,KS Krauter - 《Nucleic Acids Research》 被引量: 22...
TNF-α是战友还是敌人,对肿瘤的双刃剑效应! 肿瘤坏死因子alpha(TNF-α)是一种由157个氨基酸组成的 17-kDa 蛋白质,为免疫细胞产生的多功能细胞因子,在细胞凋亡和存活以及免疫和炎症中发挥关键作用[1]。 它主要由活化的巨噬细胞、T 淋巴细胞和自然杀伤 (NK...
目前秋水仙碱、NSAIDs和糖皮质激素等一线用药在急性痛风性关节炎治疗方面发挥着重要作用,但仍有部分患者不能达到预期治疗效果。痛风急性发作过程中有多种炎性细胞、炎性因子参与,其中IL-1在炎症激活和维持中发挥了核心作用。除此之外TNF-α...
factor2alpha TNF2 是由巨噬细胞 单核细胞活化产生的一种细胞因 子 在炎症反应 细胞免疫 肿瘤免疫等多种生理和 病理过程中发挥关键作用 TNF2 被认为是最有前 途的抗肿瘤药物之一 但是TNF2 引起严重的毒副 反应限制了其在临床的广泛应用 有关TNF2 信号 传导通路的研究一直是生物医学研究领域的热点 本文将重点...
Activation of NF-kB occurs via β-Adrenergic receptor dependent pathway by ISO38. In inflammation and apoptosis, NF-kB acts as a key regulator. In MI, phoshporylation of NF-kB induces pro-inflammatory cytokines such as TNF-α, IL-6, IL-139. Pre-treatment with GA, SA, RV and COMB ...
In addition, Sildenafil improved ulcerative colitis induced with acetic acid, possibly via impeding nuclear factor kappa beta 1/Tumor necrosis factor alpha (NF-κB1/TNF-α) signaling reliant on nuclear-related factor/ heme oxygenase (Nrf-2/HO-1) pathway [13]. ...
The Hedgehog (Hh) signaling pathway regulates a variety of tumor-related diseases, including leukemia. The present study aimed to determine whether there was an interaction between the Hh signaling pathway and transforming growth factor (TGF)-β in the KG-1 cell line. KG-1 cells were treated ...
Nevertheless, careful interpretation of findings in mouse models and critical consideration of their limitations might result in a new understanding of this complex pathway in hepatocarcinogenesis and thus might help identify the most promising targets in the TNF pathway and the appropriate clinical ...
发现,黑骨藤活性成分对RA的积极作用的机制可能为抗炎作用,促进胶原分解代谢,对转录因子的调控等多种方式,其中可能通过TNF signaling pathway,丝裂原活化蛋白激酶(MAPK)signaling pathway,NF-kappa B signaling pathway等发挥作用。关键靶点寻找和分子对接结...
(also called TNF-alpha). In contrast, TNFR2 is expressed in limited cells such as CD4 and CD8 T lymphocytes, endothelial cells, microglia, oligodendrocytes, neuron subtypes, cardiac myocytes, thymocytes and human mesenchymal stem cells. It is the receptor for both TNF and LTA (also called TNF...