Inhibition of furin-like enzymes blocks interleukin-1alpha/oncostatin M-stimulated cartilage degradation. Arthritis Rheum 2003;48:1057-66.Milner JM, Rowan AD, Elliott SF, Cawston TE (2003) Inhibition of furin-like enzymes blocks interleukin-1alpha/ oncostatin M-stimulated cartilage degradation. ...
The Notch1 receptor is cleaved constitutively by a furin-like convertase The Notch receptor, which is involved in numerous cell fate decisions in invertebrates and vertebrates, is synthesized as a 300-kDa precursor molecule (p30... F Logeat,C Bessia,C Brou,... - 《Proc Natl Acad Sci U S...
An isolated chimeric GLP-1 nucleic acid sequence encoding a human pro-insulin leader, a glucagon-like peptide-1 (GLP-1), and a furin cleavable site between the human pro-insulin leader sequence and the GLP-1 is provided. Also provided is an isolated modified chimeric GLP-1 nucleic acid seq...
We report here that constitutive processing of murine Notch1 involves a furin-like convertase. We show that the calcium ionophore A23187 and the 伪 1-antitrypsin variant, 伪 1-PDX, a known inhibitor of furin-like convertases, inhibit p300 processing. When e...
FurinGlycoproteinPro-proteinaseLiver endothelial differentiation-associated protein-1 (LEDA-1/PIANP) is a type-I-transmembrane protein first identified by us as a putative junctional protein in liver sinusoidal endothelial cells. Others have shown that LEDA-1/PIANP binds and activates immune inhibitory ...
Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network. J. Biol. Chem. 278 :18478–18484. [ PubMed ]Leighton M, Kadler KE (2003) Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the tran s-Golgi network. J Biol Chem 278 ...
Imamura, Y., Steiglitz, B.M., and Greenspan, D.S. (1998) Bone morphogenetic protein-1 processes the NH2-terminal propeptide and furin-like proprotein convertase processes the COOH-terminal propeptide of pro- 1(V) collagen J. Biol. Chem. 273, 27511-27517...
(1996) Human lactase-phlorizin hydrolase is not processed by furin, PC1/PC3, PC2, PACE4 and PC5/PC6A of the family of subtilisin-like proprotein processing proteases. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1311 , 199-203 Online publication date: 1-May-1996. /...
Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases. J Biol Chem. 2002; 277 :5596–5602.Unsold C, Pappano WN, Imamura Y, Steiglitz BM, Greenspan DS. Biosynthetic processing of the pro- α...
Serpin-like properties of alpha1-antitrypsin Portland towards furin convertase. FEBS Lett 1998; 426: 41-46.Dufour EK, Denault J-B, Hopkins PC, Leduc R (1998) Serpin-like properties of α1-antitrypsin Portland towards furin convertase. FEBS Lett 426(1):41–46. : 10.1016/S0014-...