Ligands (Delta-like -1, 3, 4 and Jagged- 1, 2) contain DSL (Delta/Serrate/LAG-2) and EGF-like repeat sequences in their extracellular domains, enabling them to interact with Notch receptors. Activation of the Notch pathway undergoes three enzymatic cleavage steps. The Notch receptor is ...
Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif J. Biol. Chem., 267 (1992), pp. 17208-17215 View PDFView articleView in ScopusGoogle Scholar 32 De Bie I., D. Savaria, A.J.M....
et al. Natural transmission of bat-like SARS-CoV-2PRRA variants in COVID-19 patients. Clin. Infect Dis. https://doi.org/10.1093/cid/ciaa953 (2020). Klimstra, W. B. et al. SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected ...
teine-rich repeats, a transmembrane domain and a short C-termi- nal cytoplasmic tail comprising 13 amino acids. CFR is highly conserved during evolution. Chicken and human CFR share more than 97% amino acid sequence homology. The function of CFR is still not completely understood. Previous ...
3A), like PIKfyve ablation or PIKfyveK1831E expression, profoundly inhibited the endosome-to-TGN transport of Tac-furin. As illustrated in Fig. 5A (panel c) the chimera was seen redistributed to peripheral punctae in cells with JLP depletion, which was observed in ∼85% of the cells (...