A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase. J Biol Chem. 2000; 275 :37712–37717.Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer...
Furin Proproteinconvertase(PC) GLG1 abstract Cysteine-richFGFreceptor(CFR)wasoriginallyidentifiedasaFGF2receptorandfoundtobeidenticalto Golgicomplex-localizedglycoprotein-1(GLG1),alsoknownasMG-160,andtoamurineE-selectin ligand-1(ESL-1).AlthoughCFRisa150-kDaintegralmembraneglycoproteinthatisprimarilylocated ...
Prediction of proprotein convertase cleavage sites Protein Eng. Des. Sel., 17 (2004), pp. 107-112 View in ScopusGoogle Scholar Frutos et al., 2021 R. Frutos, J. Serra-Cobo, L. Pinault, M. Lopez Roig, C.A. Devaux Emergence of bat-related betacoronaviruses: hazard and risks Front. ...
(P2-P2′) as a substrate revealed the prohormone convertases, or Furins, as strong candidates for cleaving at this sequence. Furins are known to cleave and activate growth factors such as nerve growth factor-beta and bone morphogenetic protein 4 intracellularly during trafficking through the ...
The proprotein convertases (PCs; genes PCSKs) constitute a family of nine serine secretory proteases that regulate various biological processes in both healthy and disease states (Seidah and Prat, 2012). By proteolysis, PCs are responsible for the activation of a wide variety of precursor proteins...
(2003). Paired basic/Furin-like pro- protein convertase cleavage of Pro-BMP-1 in the trans-Golgi network. J. Biol. Chem. 278, 18478-18484.Leighton M, Kadler KE. Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP- 1 in the trans-Golgi network. The Journal of Biological ...
Furin-like Proteasedoi:10.1007/3-540-29832-0_639Furin-like protease is a prohormone convertase, a pro-protein-processing enzyme with cleavage selectivity for paired basic amino acid residues. EndothelinsSpringer Berlin HeidelbergEncyclopedic Reference of Molecular Pharmacology...
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7. Gut 2008;57:1573 - 1582.Scamuffa N, Basak A, Lalou C, Wargnier A, Marcinkiewicz J, Siegfried G, Chretien M, Calvo F, Seidah N G and Khatib A M (2008) ...
P. (1999b) Family of prohormone convertases in Lymnaea: characterization of two alternatively spliced furin-like transcripts and cell-specific regula- tion of their expression. J. Neurobiol. 41, 399-413.Spijker, S., August, B.S., Sharp-Baker, H.E., Van Elk, R., Van Kes...
The proprotein convertases (PCs) furin, PC5/6, and PACE4 exhibit unique and/or complementary functions. Their knockout (KO) in mice resulted in strong and specific phenotypes demonstrating that, in vivo, these PCs are unique and essential during development. However, they also exhibit redundant...