Lack of ITK results in spontaneous memory acquisition in [alpha][beta] T cells termed "innate memory phenotype (IMP) T cells". The development and function of IMP T cells, and the role of ITK in their development remains unknown. This dissertation describes an alternative bone marrow ...
A reduction in Il2 transcription results in impaired FoxP3+CD4+ Treg-cell recruitment and function, and accounts for the association between murine Il2 and type 1 diabetes (T1D). The progression of T1D elicits a disease-countering negative feedback regulatory loop that involves the differentiation...
Next, the adoptive transfer of ILC2s into Rag2−/−Il2rg−/−mice, which lack T cells, B cells, NK cells, and ILCs, was performed. ILC2s from the lung of IL-33-treated mice were adoptively transferred into Rag2−/−Il2rg−/−mice, followed by UVB radiation (Fig.2a)....
A reduction in Il2 transcription results in impaired Fox P3 CD4 Treg-cell recruitment and function, and accounts for the association between murine Il2 and type 1 diabetes ( T1 D). The progression of T1 D elicits a disease-countering negative feedback regulatory loop that in...
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type... G ...
Interleukin-2 and its downstream target STAT5 have effects on many aspects of immune function. This has been perhaps best documented in regulatory T cells. In this review we summarize the initial findings supporting a role for IL2 and STAT5 in regulatory T cell development and outline more rece...
1. The IL2R α chain was generally very low on most DC before incubation, but the expression increased strikingly after overnight incubation with GM-CSF. These results confirm those obtained by others (5–12), with extension of the data to LN DC. The expression of IL-2Rα was induced ...
AA Postigo - 《Journal of Experimental Medicine》 被引量: 180发表: 1991年 Differential effects of IL12 and IL2 on expression and function of cellular adhesion molecules on purified human natural killer cells Accessory functions of cellular adhesion molecules (CAM) in activation, adhesion, migration,...
STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: functional dissection of the Il2ra gene locus. Proc. Natl Acad. Sci. USA 114, 12111–12119 (2017). Article CAS PubMed PubMed Central Google Scholar Zhao, Y. et al. A new role for STAT3 as a ...
X., and Rhodes, D., 1991, Patients with HIV infection have a reduced proportion of lymphocytes expressing the IL2 receptor p55 chain (TAC., CD25), Clin. Immunol. Immunopathol. 59:16–25. Article PubMed CAS Google Scholar Zupo, S., Rugari, E., Dono, M., Taborelli, G., Malavasi,...