Inhibition of IκKα/β with a novel selective inhibitor reproduced the impaired monocyte phenotype with decreased production of TNF-α, IL-6, IL-12p70, IL-10, GM-CSF, VEGF, MIP-1β, TNF-β, IFN-α2 and IL-7 in response to an LPS challenge. Surgical patients with infection also ...
Craft1, Serena L. M. Craft1 & Cuong Q. Nguyen1,2 Interleukin (IL)-17 is one of the critical inflammatory cytokines that plays a direct role in development of Sjögren's syndrome (SjS), a systemic autoimmune disease characterized by a progressive chronic attack against the ...
Sustained intratumoral delivery of IL-12 and GM-CSF can overcome tumor immune suppression and promote T cell-dependent eradication of established disease in murine tumor models. However, the antitumor effector response is transient and rapidly followed by a T suppressor cell rebound. The mechanisms th...
Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong structural relationship that includes a shared p40 subunit,... BS Mckenzie,RA Kastelein,DJ Cua - 《Trends in Immunology》 被引量: 0发表: 2006年 The cytoplasmic tail of the human respiratory sync...
Abstract Condoms effectively prevent against HIV, especially when used in conjunction with biomedical strategies such as PrEP and viral suppression. However, consistent use of condoms in the real world has been a continual health promotion challenge, even among populations at highest risk, such as yo...
High Rab3C expression levels promote tumor metastasis, which is associated with poor prognosis in CRC by modulating the secretion of IL-6 through exocytosis and activating the JAK2-STAT3 signaling pathway (Chang et al.2017). Furthermore, Ruxolitinib, a JAK2-specific inhibitor, is demonstrated to ...
Lipopolysaccharide-stimulated transcriptions of IL-1 and IL-12 p40 in RAW264 were inhibited by -carotene but not by ±-tocopherol. These results indicate that -carotene, which can modulate the intracellular redox status of macrophages by enhancing the level of intracellular glutathione, is related ...
Interleukin 4 (IL-4) has a variety of immune functions, including helper T-cell (Th-cell) differentiation and innate immune-response processes. However, the impact of IL-4 on gamma delta (γδ) T cells remains unclear. In this study, we investigate the effects of IL-4 on the activation...
This work uses the model of Batf3 deficiency to confirm early reports of cDC1s as a source of IL-12 during innate immune responses in mice. Article CAS PubMed PubMed Central Google Scholar Askenase, M. H. et al. Bone-marrow-resident NK cells prime monocytes for regulatory function ...
1l), and lower levels of IL-10 (Fig. 1m), suggesting that they were exposed to the bacterial species that might have migrated from the gut. Our results are in contrast with previous data obtained in dextran sodium sulfate (DSS)-treated MIF-KO mice. In this colitis model, the absence ...