For the many years, the central dogma of molecular biology has been that RNA functions mainly as an informational intermediate between a DNA sequence and its encoded protein. But one of the great surprises of modern biology was the discovery that protein-coding genes represent less than 2% of t...
In blood and urine, [68Ga]Ga-PSMA-Tz existed mainly in the form of the parent compound at 60 min p.i. (Additional file 1: Figure S13). The excellent stability both in vitro and in vivo provided prerequisites to realize the click-mediated pre-targeted in vivo. [68Ga]Ga-PSMA-Tz ...
Reportedly, HMGB1 released from damaged cells could induce a metabolic shift from glucose-dependent aerobic respiration to glycolysis via the suppression of the dimeric form of PKM2 [46]. In metabolic flux assays, LPS significantly enhanced glycolysis, but inhibited OXPHOS in primary microglia [47]....
Full form of IFFCO: Here, we are going to learn about the IFFCO, full form of IFFCO, overview, history, vision, objectives, awards, etc. By Anushree Goswami Last updated : April 4, 2024 IFFCO: Indian Farmers Fertilizer Cooperative Limited...
Microbiome alterations have been associated with depression, and fecal transfer of depressed patients’ microbiomes is sufficient to enhance despair behaviors in rodents. Yet little is known about the potential mechanisms, whereby microbes modulate depre
Pignoni F, Hu B, Zavitz KH, Xiao J, Garrity PA, Zipursky SL: The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell. 1997, 91: 881-891. 10.1016/S0092-8674(00)80480-8. Article PubMed CAS Google Scholar Chen R, Amo...
While BMP signaling plays a central role in instructing pluripotent cells to form epidermis, it is the other branch of the TGF-beta that directs mesendodermal fates. Members of the Activin/ Nodal/Vg1/GDF1/TGF-beta subfamily act via pSmad2/3 to activate mesodermal and endodermal target ge...
The quick links are meant to take a revisiting user directly to a feature of interest. Using the first option “Query”, the database may be explored under the following categories - Disease, Gene, Protein, Polymorphism and Pathway. The class “Disease” contains the list of genes grouped ...
As in eukaryotes, precursor transfer RNAs in Archaea often contain introns that are removed in tRNA maturation. Two unrelated archaeal species display unique pre-tRNA processing complexity in the form of split tRNA genes, in which two to three segments o
This methodology extends to this class of materials the possibility to evaluate both the elastic modulus and the tensile strength with a single mechanical test, without the need for other experimental tools. Significant recent advancements achieved in manufacturing technology, including the new ...