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For the many years, the central dogma of molecular biology has been that RNA functions mainly as an informational intermediate between a DNA sequence and its encoded protein. But one of the great surprises of modern biology was the discovery that protein-coding genes represent less than 2% of t...
Reportedly, HMGB1 released from damaged cells could induce a metabolic shift from glucose-dependent aerobic respiration to glycolysis via the suppression of the dimeric form of PKM2 [46]. In metabolic flux assays, LPS significantly enhanced glycolysis, but inhibited OXPHOS in primary microglia [47]....
KEY_INFORMATION_CLASS enumeration KEY_NODE_INFORMATION structure KEY_SET_INFORMATION_CLASS enumeration KEY_VALUE_BASIC_INFORMATION structure KEY_VALUE_ENTRY structure KEY_VALUE_FULL_INFORMATION structure KEY_VALUE_INFORMATION_CLASS enumeration KEY_VALUE_PARTIAL_INFORMATION structure KEY_WRITE_TIME_INFORMATION st...
In blood and urine, [68Ga]Ga-PSMA-Tz existed mainly in the form of the parent compound at 60 min p.i. (Additional file 1: Figure S13). The excellent stability both in vitro and in vivo provided prerequisites to realize the click-mediated pre-targeted in vivo. [68Ga]Ga-PSMA-Tz ...
Microbiome alterations have been associated with depression, and fecal transfer of depressed patients’ microbiomes is sufficient to enhance despair behaviors in rodents. Yet little is known about the potential mechanisms, whereby microbes modulate depre
This methodology extends to this class of materials the possibility to evaluate both the elastic modulus and the tensile strength with a single mechanical test, without the need for other experimental tools. Significant recent advancements achieved in manufacturing technology, including the new ...
As in eukaryotes, precursor transfer RNAs in Archaea often contain introns that are removed in tRNA maturation. Two unrelated archaeal species display unique pre-tRNA processing complexity in the form of split tRNA genes, in which two to three segments o
As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community