The role of mitochondrial dynamics, encompassing fission, fusion, and mitophagy, in cancer progression has been extensively studied. However, the specific impact of mitochondrial dynamics on hepatocellular carcinoma (HCC) is still under investigation. In
2D representations are produced in the form of SVG images, whereas 3D representations are returned as HTML files containing embedded JSMol objects [57, 58]. Through REST API calls, the tools and ocsr modules offer convenient access to the underlying functionalities of the integrated tools. For ...
HCC cells with the retinoblastoma (RB) protein deficiency had 2–3 times higher death rate more than that of cells with a normal level of RB protein [71]. This susceptibility of HCC with deactivated RB protein to ferroptosis was due to the augment of oxidative stress response in cells from...
In this study, we established a 3D invasion model and found that CD147 promoted 3D invasion of HCC cells regardless of MMPs activity. Protease expression profiling showed that CD147 may regulate a panel of proteases besides MMPs. Among these, expression of cathepsin B was significantly down-regul...
Secondary objectives included immunogenicity, PK, and PD of QL1706. In phase Ib, QL1706 was administered at the RP2D intravenously once every 3 weeks in patients with NSCLC, nasopharyngeal carcinoma (NPC), cervical cancer (CC), CRC, small cell lung cancer (SCLC), HCC, and other solid ...
In hepatocellular carcinoma, expressions of TRIM proteins are both regulated by genetic and epigenetic mechanisms. TRIM proteins regulate multiple biological activities and signaling cascades. And TRIM proteins influence hallmarks of HCC. This review systematically demonstrates the versatile roles of TRIM ...
Hepatocellular carcinoma (HCC) is among the most common malignancies worldwide and is characterized by high rates of morbidity and mortality, posing a serious threat to human health. Interventional embolization therapy is the main treatment against middl
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, poses a significant global health burden with its high incidence and mortality rate [1, 2]. The complex and diverse molecular nature of HCC between different tumors and even within the same tumor, manifesting as tumor...
However, metastatic breast cancer cells can induce neutrophils to form NETs, thus supporting tumor metastasis [2]. In the process of establishing a pre-metastatic niche, NET-associated neutrophils promote the recruitment of neutrophils with the potential to form NETs by degrading anti-tumor factors ...
samples. However, the samples used for the RNA-seq analysis are usually prepared in the form of bulk tissues which might consist of various types of cells. Such a bulk-tissue RNA-seq approach measures only the average gene expression profiles (GEP) of various cell types contained in a ...