Sorafenib (Nexavar®) is the singular systemic agent used in advanced HCC that is approved by the Food and Drug Administration. Based on the results of Phase III trials of Sorafenib Asia-Pacific and pivotal Sorafenib Hepatocellular carcinoma Assessment Randomized Protocol trials in advanced HCC patie...
Full size table These Six independent predictors were utilized to form an MVI-predicting nomogram (Fig. 3a). The nomogram provided good accuracy in estimating the risk of MVI, with C index of 0.79 (95%CI: 0.72–0.86), R2 of 0.35, discrimination index (D index) of 0.30, Brier score of...
the genome for HCC‑specific CpG methylation signatures as biomarkers for diagnosis and prognosis evaluation Rui‑kun Zhang1 and Jia‑lin Liu2* Abstract Background: Hepatocellular carcinoma (HCC) is one of the most common and invasive malignant tumors in the world...
Solutions 13 Effective Leadership & Management Skills The Leader in Each of Us In today's competitive work environment, it is important that employees at all levels of the organization take full responsibility for their contribution, the success of others, and the ultimate success of their employer...
Full size image Lenvatinib-resistant cells present transcriptionally upregulated glycolytic metabolism in cell competition condition To uncover the biological mechanism of underlying cell competition between lenvatinib-resistant HCC cells and sensitive HCC cells, we separated the cocultured cells including CCHuh...
In a separate Phase 3 trial of YERVOY 3 mg/kg, severe, life-threatening, or fatal immune-mediated dermatitis (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, or rash complicated by full thickness dermal ulceration, or necrotic, bullous, or hemorrhagic manifestations; Grade ...
Full size image Ensor et al. [7] found that the circulation half-life of ADI (a few hours) was prolonged by pegylation. The pegylated ADI had a circulation half-life of 2–3 days. Although the native ADI enzyme and the pegylated ADI were similar in their ability to inhibit the growth...
miRNAs are considered promising non-invasive biomarkers. Serum represents the major source of biomarkers, being readily accessible for many analytical tests. Recently, whole blood has drawn increasing interest in biomarker studies due to the presence of
Full size image We further investigated the expression changes of HLA genes pre- and post- the neoadjuvant therapy. The analysis of the gene expression heatmaps revealed a significant upregulation in both HLA class I and class II genes following treatment (Fig.8a). Notably, a more pronounced ...
lacks defining mutations observed in many other cancers. This has contributed to the lack of success of molecularly targeted agents in HCC. The limited overall benefit, taken together with the poor overall prognosis for patients with...