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The importance of HCC codingLori Zimmerman
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The active methyl group is transferred from S-adenosylmethionine to the 5-carbon position of cytosine to form 5-methyl- cytosine, changing the DNA conformation, stability, and protein interactions, thereby regulating gene expression [4]. Abnormally high methylation of CpG islands in the promotor ...
Full size image To further confirm the findings from RNA-seq analysis, we examined the levels of cellular 2-NBDG, the indigestible glucose analog as a marker for glycolysis [21,22], in cells from a myriad of models in vitro. Notably, both CCHuh7R and CCPLC-PRF-5R displayed higher 2-...
Moreover, the immuno- fluorescence staining results demonstrated significant co- localization of CD147 with ADAM10 in HCC cells (Figure 2c). The immunoprecipitation results also revealed that CD147 and ADAM10 could form a complex in vitro (Figure 2d). Here, cholesterol deprivation from lipid rafts...
Journal of Hepatocellular Carcinoma Dovepress open access to scientific and medical research Open Access Full Text Article REVIEW Elucidating the Molecular Basis of Sorafenib Resistance in HCC: Current Findings and Future Directions Francesca Fornari 1,2 Catia Giovannini1,3 Fabio Piscaglia 4,5 Laura ...
Full size image EGR1 downregulation prompted HCC cells proliferation in vitro and facilitated tumor growth in vivo To investigate the role of EGR1 in HCC, we conducted an analysis of EGR1 protein expression in both normal liver cell line and HCC cell lines. Our findings revealed that HCC cell...
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