Adipose-derived stem cells (ADSCs) have been extensively used in preclinical and clinical trials for treating various diseases. However, the differences between ADSCs from lean individuals (L-ADSCs) and those from obese individuals (O-ADSCs) have not bee
a form of continuous cultivation with full biomass retention. Retentostats are typically initiated from steady-state chemostat cultures. In cases where the energy (and usually also carbon) source is limiting, the respective specific nutrient uptake rate (qS) asymptotically...
Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMPK. However, the role of
L-tyrosine is a common precursor for a wide range of valuable secondary metabolites, including benzylisoquinoline alkaloids (BIAs) and many polyketides. An industrially tractable yeast strain optimized for production of L-tyrosine could serve as a platfo
In turn, apical sodium-dependent bile acid transporter (ASBT) [35] plays a pivotal role in the transport of cholesterol present in bile. The free cholesterol from enterocytes is then “pumped” back into the small intestine lumen via transporters—ATP-binding cassette sub-family G member 5/...
This emphasizes the importance of metals in biology and highlights their remarkable role in conferring proteins with unique properties [14]. The dependence of all organisms on metalloproteins arises from the unique properties that metals confer to polypeptide chains. Metals in metalloproteins can form ...
Evolution of the deuterostome lineage was accompanied by an increase in systematic complexity especially with regard to highly specialized tissues and organs. Based on the observation of an increased number of paralogous genes in vertebrates compared wit
In addition to biosysnthesis genes, many of these gene clusters also encode efflux pumps with putative roles in siderophore export. Transporters classified within the ATP-binding cassette (ABC) superfamily, major facilitator superfamily (MFS) and resistance-nodulation-cell division (RND) family have ...
Guanylate binding protein 1 (GBP1) is the most concerned member of the GBP family, which has a series of effects such as anti-infection and anti-angiogenesis. Its role in malignant tumors including cervical cancer is still controversial. We aim to explor
Roots are an attractive system for genomic and post-genomic studies of NaCl responses, due to their primary importance to agriculture, and because of their relative structural and biochemical simplicity. Excellent genomic resources have been established