Abnormalities of immunoglobulin free light chains (FLCs) are frequently present in patients with monoclonal gammopathies and can cause kidney disease. The recent introduction of highly sensitive immunoassays that measure FLCs to levels below those present in normal individuals has provided a new tool ...
Related to light chain:Myosin light chain kinase n. Either of the two smaller polypeptide chains in an immunoglobulin molecule, consisting of an antigen-binding portion with a variable amino acid sequence and a constant region that occurs in two different forms in humans. ...
Free light chains will normally be present in the blood at low levels, with a kappa/lambda ratio of approximately 0.26 to 1.65 for individuals with normal kidney function. Increased kappa free light chains and an increased kappa/lambda ratio may be seen with plasma cell disorders that produce ...
Free light chains: author's response 来自 Semantic Scholar 喜欢 0 阅读量: 1 作者: J Sheldon 摘要: I am very pleased to be part of a debate about the serum free light chain (FLC) assay. I am also encouraged that we all agree that measuring monoclonal proteins is difficult and that it...
The value of serum free light chains in a case of Waldenstrom's macroglobulinaemia that produces a type I cryoglobulinae- mia. Ann Clin Biochem 2009;... RJ Pattenden,KL Davidson,PR Wenham - 《Annals of Clinical Biochemistry》 被引量: 2发表: 2009年 Update on treatment recommendations from ...
Hutchison CA, Harding S, Hewins P, Mead GP, Townsend J, Bradwell AR, Cockwell P: Quantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease. Clin J Am Soc Nephrol 3: 1684-1690, 2008...
2023, Journal of Applied Laboratory Medicine In response to: Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: results of the iStopMM study 2022, Blood Cancer Journal View all citing articles on ScopusView...
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Normalization of serum-free light chains in patients with systemic lupus erythematosus upon rituximab treatment and correlation with biological disease act... Increased free light chain (FLC) levels have been reported as useful in various autoimmune conditions. We investigated how FLC concentrations change...
In contrast, serum IgG and IgA concentrations are not prognostic in MM. Novel immunoassays have been developed which target the specific conformational, junctional epitopes between the heavy and light chains of the immunoglobulin making it possible to measure Ig'kappa and Ig'lambda and produce an ...