Serum free light chain measurements in screening for lymphoproliferative diseases-comparison recommended and renal reference interval for free light chain ratio in patients with renal failure 来自 Semantic Scholar 喜欢 0 阅读量: 12 作者:Z. ermáková,M Dastych,J Gottwaldová ...
Renal failure due to a monoclonal gammopathy may be detected by the highly sensitive serum-free light-chain (sFLC) ratio yet missed by electrophoretic assays. The aim of this study was to assess sFLC levels in relation to markers of renal function. Methods: Five-hundred thirteen patients were ...
The N Latex FLC κ/λ ratio in the CKD5 group (0.69, 0.32-1.54) was significantly lower compared with the control group (p<0.0001).These findings demonstrate that the N Latex FLC κ/λ ratio in patients with renal failure did not differ from the reference limits for healthy controls....
Increased lambda free light chains and a decreased kappa/lambda ratio may be seen with plasma cell disorders that produce excess monoclonal lambda light chains. In the context of MGUS or myeloma, significantly increased free light chain production and a markedly abnormal kappa/lambda ratio indicate ...
Background: The aim of this study was to establish ranges for N Latex free light-chain (FLC) monoclonal-based nephelometric assays in patients with renal impairment. Methods: In this retrospective study, serum samples from 284 patients with chronic kidne
Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood. 2005;106(3):812–7. Article PubMed Central CAS PubMed Google Scholar Dispenzieri A, Stewart AK, Chanan-Khan A, Rajkumar SV, Kyle RA, Fonseca R, et al....
Acute renal failure in multiple myeloma is most frequently caused by cast nephropathy, when excess monoclonal free light chains co-precipitate with Tamm-Horsfall protein in the distal nephron, causing tubular obstruction. The natural history of cast neph
Define residually. residually synonyms, residually pronunciation, residually translation, English dictionary definition of residually. adj. 1. Of, relating to, or characteristic of a residue. 2. Remaining as a residue. n. 1. The quantity left over at the
(B) The receiver operating characteristic curve for κ and λ serum free light chains distinguished patients with renal involvement from patients without. sFLC serum free light chains, PPV positive predictive value, NPV negative predictive value, PLR positive likelihood ratio, NLR negative likelihood ...
One extreme value of FLCk (592 mg l À 1) with a highly abnormal FLC ratio of 619 suggesting undiagnosed multiple myeloma/B-cell dyscrasia was excluded. In descriptive statistics, Mann–Whitney U test was used to assess the difference in distribution of sFLC and albumin between the HCC ...