A good correlation was demonstrated between both assays, but it remained 7.6% to 20.8% discordances between the methods related to the FLC ratio interpretation. In patient follow-up, few discrepancies were observed. Neither of the assays performed better than the other: they provide comparable but...
KB was chiefly responsible for the gathering, analysis and interpretation of data, creation of the figures for this report and was responsible for writing the manuscript. DK and MS performed histological examination of the renal biopsies and were major contributors to the content of the manuscript....
Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood. 2005;106(3):812–7. Article PubMed Central CAS PubMed Google Scholar Dispenzieri A, Stewart AK, Chanan-Khan A, Rajkumar SV, Kyle RA, Fonseca R, et al....
There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ). The quantification of serum FLC is used as an aid in the diagnosis and monitoring patients with Multiple Myeloma. Ratio FLC value (kappa FLC/lambda FLC) compared to reference ranges ...
Caution is urged in the interpretation of results of serum-free light chain assay, kappa/lambda ratio, and myeloma defining conditions. The distortions in serum-free light chain assay and development of oligoclonal bands in patients' status post hematopoietic stem cell transplants is emphasized and...
Kappa free light chain (KFLC), expressed through different interpretation approaches, in patients with radiological or clinically isolated syndrome (RIS-CIS) according to conversion to multiple sclerosis (MS) after a minimum follow up of one year. Mean values were: CSF KFLC/IgG ratio 71.5 (±...
One extreme value of FLCk (592 mg l À 1) with a highly abnormal FLC ratio of 619 suggesting undiagnosed multiple myeloma/B-cell dyscrasia was excluded. In descriptive statistics, Mann–Whitney U test was used to assess the difference in distribution of sFLC and albumin between the HCC ...
Define Iris pallida. Iris pallida synonyms, Iris pallida pronunciation, Iris pallida translation, English dictionary definition of Iris pallida. Noun 1. Iris pallida - European iris having soft lilac-blue flowers Dalmatian iris bearded iris - any of nume
In the last years, however, free light chain (FLC) testing in serum became one important pillar in the diagnosis and monitoring of Multiple Myeloma and related disorders such as Amyloidosis, most of these diseases occurring in older patients. In particular, the ratio of κ FL...
Although it is a simple technique, digestion deserves a special care since the use of immobilized enzymes is highly recommended to avoid back exchange that can occur during sample mixing (labeled and unlabeled), altering 16O/18O ratio. Moreover, partial labeling can easily occur and can ...